Induction of HO-1 by Mevastatin Mediated via a Nox/ROS-Dependent c-Src/PDGFRα/PI3K/Akt/Nrf2/ARE Cascade Suppresses TNF-α-Induced Lung Inflammation

Background: Mevastatin (MVS), a 3-hydroxy-3-methylglutaryl coenzyme, a reductase (HMG-CoA) inhibitor, has anti-inflammatory effects potentially via up-regulation of heme oxygenase-1 (HO-1). However, the mechanisms underlying MVS-induced HO-1 expression remain largely unknown in human pulmonary alveo...

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Detalles Bibliográficos
Autores principales: Lin, Chih-Chung, Lin, Wei-Ning, Cho, Rou-Ling, Yang, Chien-Chung, Yeh, Yi-Cheng, Hsiao, Li-Der, Tseng, Hui-Ching, Yang, Chuen-Mao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019964/
https://www.ncbi.nlm.nih.gov/pubmed/31952230
http://dx.doi.org/10.3390/jcm9010226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019964/
https://www.ncbi.nlm.nih.gov/pubmed/31952230
http://dx.doi.org/10.3390/jcm9010226

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