Cargando…

Changes in Age at Diagnosis and Nutritional Course of Celiac Disease in the Last Two Decades

The frequency of celiac disease (CD) has increased along time, with relevant changes reported in geographical variations, clinical presentation and nutritional repercussions. In recent years, some celiac patients are presenting overweight/obesity, but it is unclear how frequent this is and to what e...

Descripción completa

Detalles Bibliográficos
Autores principales: Villanueva, Mónica, Oyarzún, Amaya, Leyton, Bárbara, González, Mónica, Navarro, Elizabeth, Canales, Paulina, Ossa, Cristobal, Muñoz, María Paz, Bascuñán, Karla A., Araya, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019995/
https://www.ncbi.nlm.nih.gov/pubmed/31935859
http://dx.doi.org/10.3390/nu12010156
_version_ 1783497648497491968
author Villanueva, Mónica
Oyarzún, Amaya
Leyton, Bárbara
González, Mónica
Navarro, Elizabeth
Canales, Paulina
Ossa, Cristobal
Muñoz, María Paz
Bascuñán, Karla A.
Araya, Magdalena
author_facet Villanueva, Mónica
Oyarzún, Amaya
Leyton, Bárbara
González, Mónica
Navarro, Elizabeth
Canales, Paulina
Ossa, Cristobal
Muñoz, María Paz
Bascuñán, Karla A.
Araya, Magdalena
author_sort Villanueva, Mónica
collection PubMed
description The frequency of celiac disease (CD) has increased along time, with relevant changes reported in geographical variations, clinical presentation and nutritional repercussions. In recent years, some celiac patients are presenting overweight/obesity, but it is unclear how frequent this is and to what extent undernutrition remains a concern. This is relevant because CD tends to be overlooked in overweight patients. With this in mind, we assessed age at diagnosis, clinical characteristics and nutritional status of 155 celiac patients diagnosed between 1994–2017 in four pediatric hospitals in Santiago, Chile. Since 2003, the number of patients diagnosed has increased (p < 0.0033), coinciding with antitransglutaminase and antiendomysial antibodies becoming available to public health systems. In 2000, 4.5% of patients were asymptomatic at diagnosis, suggesting that active search is not routinely applied. Gastrointestinal symptoms plus failure to thrive were significantly more frequent under 2 years (p = 0.0001). Nutritional status has improved at diagnosis and during follow up, but undernutrition remains more frequent in children <2 and <5 years (p < 0.002 and p < 0.0036, respectively). Overweight at diagnosis was reported in 2002 and obesity in 2010. After initiating treatment, since 2010, patients changing from undernourishment to overweight has sometimes been observed after only 6 months on a gluten-free diet.
format Online
Article
Text
id pubmed-7019995
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-70199952020-03-09 Changes in Age at Diagnosis and Nutritional Course of Celiac Disease in the Last Two Decades Villanueva, Mónica Oyarzún, Amaya Leyton, Bárbara González, Mónica Navarro, Elizabeth Canales, Paulina Ossa, Cristobal Muñoz, María Paz Bascuñán, Karla A. Araya, Magdalena Nutrients Article The frequency of celiac disease (CD) has increased along time, with relevant changes reported in geographical variations, clinical presentation and nutritional repercussions. In recent years, some celiac patients are presenting overweight/obesity, but it is unclear how frequent this is and to what extent undernutrition remains a concern. This is relevant because CD tends to be overlooked in overweight patients. With this in mind, we assessed age at diagnosis, clinical characteristics and nutritional status of 155 celiac patients diagnosed between 1994–2017 in four pediatric hospitals in Santiago, Chile. Since 2003, the number of patients diagnosed has increased (p < 0.0033), coinciding with antitransglutaminase and antiendomysial antibodies becoming available to public health systems. In 2000, 4.5% of patients were asymptomatic at diagnosis, suggesting that active search is not routinely applied. Gastrointestinal symptoms plus failure to thrive were significantly more frequent under 2 years (p = 0.0001). Nutritional status has improved at diagnosis and during follow up, but undernutrition remains more frequent in children <2 and <5 years (p < 0.002 and p < 0.0036, respectively). Overweight at diagnosis was reported in 2002 and obesity in 2010. After initiating treatment, since 2010, patients changing from undernourishment to overweight has sometimes been observed after only 6 months on a gluten-free diet. MDPI 2020-01-06 /pmc/articles/PMC7019995/ /pubmed/31935859 http://dx.doi.org/10.3390/nu12010156 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Villanueva, Mónica
Oyarzún, Amaya
Leyton, Bárbara
González, Mónica
Navarro, Elizabeth
Canales, Paulina
Ossa, Cristobal
Muñoz, María Paz
Bascuñán, Karla A.
Araya, Magdalena
Changes in Age at Diagnosis and Nutritional Course of Celiac Disease in the Last Two Decades
title Changes in Age at Diagnosis and Nutritional Course of Celiac Disease in the Last Two Decades
title_full Changes in Age at Diagnosis and Nutritional Course of Celiac Disease in the Last Two Decades
title_fullStr Changes in Age at Diagnosis and Nutritional Course of Celiac Disease in the Last Two Decades
title_full_unstemmed Changes in Age at Diagnosis and Nutritional Course of Celiac Disease in the Last Two Decades
title_short Changes in Age at Diagnosis and Nutritional Course of Celiac Disease in the Last Two Decades
title_sort changes in age at diagnosis and nutritional course of celiac disease in the last two decades
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019995/
https://www.ncbi.nlm.nih.gov/pubmed/31935859
http://dx.doi.org/10.3390/nu12010156
work_keys_str_mv AT villanuevamonica changesinageatdiagnosisandnutritionalcourseofceliacdiseaseinthelasttwodecades
AT oyarzunamaya changesinageatdiagnosisandnutritionalcourseofceliacdiseaseinthelasttwodecades
AT leytonbarbara changesinageatdiagnosisandnutritionalcourseofceliacdiseaseinthelasttwodecades
AT gonzalezmonica changesinageatdiagnosisandnutritionalcourseofceliacdiseaseinthelasttwodecades
AT navarroelizabeth changesinageatdiagnosisandnutritionalcourseofceliacdiseaseinthelasttwodecades
AT canalespaulina changesinageatdiagnosisandnutritionalcourseofceliacdiseaseinthelasttwodecades
AT ossacristobal changesinageatdiagnosisandnutritionalcourseofceliacdiseaseinthelasttwodecades
AT munozmariapaz changesinageatdiagnosisandnutritionalcourseofceliacdiseaseinthelasttwodecades
AT bascunankarlaa changesinageatdiagnosisandnutritionalcourseofceliacdiseaseinthelasttwodecades
AT arayamagdalena changesinageatdiagnosisandnutritionalcourseofceliacdiseaseinthelasttwodecades