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H7N9 Influenza Virus Containing a Polybasic HA Cleavage Site Requires Minimal Host Adaptation to Obtain a Highly Pathogenic Disease Phenotype in Mice

Low pathogenic avian influenza (LPAI) H7N9 viruses have recently evolved to gain a polybasic cleavage site in the hemagglutinin (HA) protein, resulting in variants with increased lethality in poultry that meet the criteria for highly pathogenic avian influenza (HPAI) viruses. Both LPAI and HPAI vari...

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Detalles Bibliográficos
Autores principales:	Chan, Mable, Leung, Anders, Hisanaga, Tamiko, Pickering, Brad, Griffin, Bryan D., Vendramelli, Robert, Tailor, Nikesh, Wong, Gary, Bi, Yuhai, Babiuk, Shawn, Berhane, Yohannes, Kobasa, Darwyn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020020/ https://www.ncbi.nlm.nih.gov/pubmed/31948040 http://dx.doi.org/10.3390/v12010065

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