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Creatinine to Body Weight Ratio Is Associated with Incident Diabetes: Population-Based Cohort Study
We investigated the association between creatinine to body weight (Cre/BW) ratio and incident diabetes. In this cohort study, 9659 men and 7417 women were follow up mean (SD) 5.6 (3.5) years and 5.4 (3.4) years, respectively. For men, tertile 1 (T1; n = 3176), Cre/BW < 0.01275; tertile 2 (T2; n =...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020036/ https://www.ncbi.nlm.nih.gov/pubmed/31952309 http://dx.doi.org/10.3390/jcm9010227 |
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author | Hashimoto, Yoshitaka Okamura, Takuro Hamaguchi, Masahide Obora, Akihiro Kojima, Takao Fukui, Michiaki |
author_facet | Hashimoto, Yoshitaka Okamura, Takuro Hamaguchi, Masahide Obora, Akihiro Kojima, Takao Fukui, Michiaki |
author_sort | Hashimoto, Yoshitaka |
collection | PubMed |
description | We investigated the association between creatinine to body weight (Cre/BW) ratio and incident diabetes. In this cohort study, 9659 men and 7417 women were follow up mean (SD) 5.6 (3.5) years and 5.4 (3.4) years, respectively. For men, tertile 1 (T1; n = 3176), Cre/BW < 0.01275; tertile 2 (T2; n = 3258), 0.01275 ≤ Cre/BW < 0.0148; and tertile 3 (T3; n = 3225), Cre/BW ≥ 0.0148; and for women, T1 (n = 2437), Cre/BMI < 0.0118; T2 (n = 2516), 0.0118 ≤ Cre/BMI < 0.014; and T3 (n = 2477), Cre/BMI ≥ 0.014. Among them, 362 men and 102 women developed diabetes. The hazard ratios (HRs) of incident diabetes in the T2 group was 0.56 (95% CI 0.44–0.71, p < 0.001) in men and 0.61 (0.38–0.99, p = 0.045) in women and in the T3 group was 0.42 (0.32–0.54, p < 0.001) in men and 0.55 (0.34–0.89, p = 0.014) in women after adjusting for covariates, compared with the T1 group. Moreover, Δ0.001 incremental of Cre/BW is negatively associated with incident diabetes (adjusted HR 0.84, 95% CI 0.80–0.88, p < 0.001 for men and 0.88, 0.81–0.96, p = 0.003 for women). In conclusion, Cre/BW ratio is inversely related to incident diabetes. Checking Cre/BW ratios may predict future diabetes risks. |
format | Online Article Text |
id | pubmed-7020036 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70200362020-03-09 Creatinine to Body Weight Ratio Is Associated with Incident Diabetes: Population-Based Cohort Study Hashimoto, Yoshitaka Okamura, Takuro Hamaguchi, Masahide Obora, Akihiro Kojima, Takao Fukui, Michiaki J Clin Med Article We investigated the association between creatinine to body weight (Cre/BW) ratio and incident diabetes. In this cohort study, 9659 men and 7417 women were follow up mean (SD) 5.6 (3.5) years and 5.4 (3.4) years, respectively. For men, tertile 1 (T1; n = 3176), Cre/BW < 0.01275; tertile 2 (T2; n = 3258), 0.01275 ≤ Cre/BW < 0.0148; and tertile 3 (T3; n = 3225), Cre/BW ≥ 0.0148; and for women, T1 (n = 2437), Cre/BMI < 0.0118; T2 (n = 2516), 0.0118 ≤ Cre/BMI < 0.014; and T3 (n = 2477), Cre/BMI ≥ 0.014. Among them, 362 men and 102 women developed diabetes. The hazard ratios (HRs) of incident diabetes in the T2 group was 0.56 (95% CI 0.44–0.71, p < 0.001) in men and 0.61 (0.38–0.99, p = 0.045) in women and in the T3 group was 0.42 (0.32–0.54, p < 0.001) in men and 0.55 (0.34–0.89, p = 0.014) in women after adjusting for covariates, compared with the T1 group. Moreover, Δ0.001 incremental of Cre/BW is negatively associated with incident diabetes (adjusted HR 0.84, 95% CI 0.80–0.88, p < 0.001 for men and 0.88, 0.81–0.96, p = 0.003 for women). In conclusion, Cre/BW ratio is inversely related to incident diabetes. Checking Cre/BW ratios may predict future diabetes risks. MDPI 2020-01-15 /pmc/articles/PMC7020036/ /pubmed/31952309 http://dx.doi.org/10.3390/jcm9010227 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hashimoto, Yoshitaka Okamura, Takuro Hamaguchi, Masahide Obora, Akihiro Kojima, Takao Fukui, Michiaki Creatinine to Body Weight Ratio Is Associated with Incident Diabetes: Population-Based Cohort Study |
title | Creatinine to Body Weight Ratio Is Associated with Incident Diabetes: Population-Based Cohort Study |
title_full | Creatinine to Body Weight Ratio Is Associated with Incident Diabetes: Population-Based Cohort Study |
title_fullStr | Creatinine to Body Weight Ratio Is Associated with Incident Diabetes: Population-Based Cohort Study |
title_full_unstemmed | Creatinine to Body Weight Ratio Is Associated with Incident Diabetes: Population-Based Cohort Study |
title_short | Creatinine to Body Weight Ratio Is Associated with Incident Diabetes: Population-Based Cohort Study |
title_sort | creatinine to body weight ratio is associated with incident diabetes: population-based cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020036/ https://www.ncbi.nlm.nih.gov/pubmed/31952309 http://dx.doi.org/10.3390/jcm9010227 |
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