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Evolution of Airway Inflammation in Preschoolers with Asthma—Results of a Two-Year Longitudinal Study

Fractional exhaled nitric oxide (FeNO) is a non-invasive marker for eosinophilic airway inflammation and has been used for monitoring asthma. Here, we assess the characteristics of FeNO from preschool to school age, in parallel with asthma activity. A total of 167 asthmatic children and 66 healthy,...

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Autores principales: Xepapadaki, Paraskevi, Korovessi, Paraskevi, Bachert, Claus, Finotto, Susetta, Jartti, Tuomas, Lakoumentas, John, Kowalski, Marek L., Lewandowska-Polak, Anna, Lukkarinen, Heikki, Zhang, Nan, Zimmermann, Theodor, Papadopoulos, Nikolaos G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020050/
https://www.ncbi.nlm.nih.gov/pubmed/31936693
http://dx.doi.org/10.3390/jcm9010187
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author Xepapadaki, Paraskevi
Korovessi, Paraskevi
Bachert, Claus
Finotto, Susetta
Jartti, Tuomas
Lakoumentas, John
Kowalski, Marek L.
Lewandowska-Polak, Anna
Lukkarinen, Heikki
Zhang, Nan
Zimmermann, Theodor
Papadopoulos, Nikolaos G.
author_facet Xepapadaki, Paraskevi
Korovessi, Paraskevi
Bachert, Claus
Finotto, Susetta
Jartti, Tuomas
Lakoumentas, John
Kowalski, Marek L.
Lewandowska-Polak, Anna
Lukkarinen, Heikki
Zhang, Nan
Zimmermann, Theodor
Papadopoulos, Nikolaos G.
author_sort Xepapadaki, Paraskevi
collection PubMed
description Fractional exhaled nitric oxide (FeNO) is a non-invasive marker for eosinophilic airway inflammation and has been used for monitoring asthma. Here, we assess the characteristics of FeNO from preschool to school age, in parallel with asthma activity. A total of 167 asthmatic children and 66 healthy, age-matched controls were included in the 2-year prospective PreDicta study evaluating wheeze/asthma persistence in preschool-aged children. Information on asthma/rhinitis activity, infections and atopy was recorded at baseline. Follow-up visits were performed at 6-month intervals, as well as upon exacerbation/cold and 4–6 weeks later in the asthmatic group. We obtained 539 FeNO measurements from asthmatics and 42 from controls. At baseline, FeNO values did not differ between the two groups (median: 3.0 ppb vs. 2.0 ppb, respectively). FeNO values at 6, 12, 18 and 24 months (4.0, CI: 0.0–8.6; 6.0, CI: 2.8–12.0; 8.0, CI: 4.0–14.0; 8.5, CI: 4.4–14.5 ppb, respectively) increased with age (correlation p ≤ 0.001) and atopy (p = 0.03). FeNO was non-significantly increased from baseline to the symptomatic visit, while it decreased after convalescence (p = 0.007). Markers of disease activity, such as wheezing episodes and days with asthma were associated with increased FeNO values during the study (p < 0.05 for all). Age, atopy and disease activity were found to be important FeNO determinants in preschool children. Longitudinal and individualized FeNO assessment may be valuable in monitoring asthmatic children with recurrent wheezing or mild asthma.
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spelling pubmed-70200502020-03-09 Evolution of Airway Inflammation in Preschoolers with Asthma—Results of a Two-Year Longitudinal Study Xepapadaki, Paraskevi Korovessi, Paraskevi Bachert, Claus Finotto, Susetta Jartti, Tuomas Lakoumentas, John Kowalski, Marek L. Lewandowska-Polak, Anna Lukkarinen, Heikki Zhang, Nan Zimmermann, Theodor Papadopoulos, Nikolaos G. J Clin Med Article Fractional exhaled nitric oxide (FeNO) is a non-invasive marker for eosinophilic airway inflammation and has been used for monitoring asthma. Here, we assess the characteristics of FeNO from preschool to school age, in parallel with asthma activity. A total of 167 asthmatic children and 66 healthy, age-matched controls were included in the 2-year prospective PreDicta study evaluating wheeze/asthma persistence in preschool-aged children. Information on asthma/rhinitis activity, infections and atopy was recorded at baseline. Follow-up visits were performed at 6-month intervals, as well as upon exacerbation/cold and 4–6 weeks later in the asthmatic group. We obtained 539 FeNO measurements from asthmatics and 42 from controls. At baseline, FeNO values did not differ between the two groups (median: 3.0 ppb vs. 2.0 ppb, respectively). FeNO values at 6, 12, 18 and 24 months (4.0, CI: 0.0–8.6; 6.0, CI: 2.8–12.0; 8.0, CI: 4.0–14.0; 8.5, CI: 4.4–14.5 ppb, respectively) increased with age (correlation p ≤ 0.001) and atopy (p = 0.03). FeNO was non-significantly increased from baseline to the symptomatic visit, while it decreased after convalescence (p = 0.007). Markers of disease activity, such as wheezing episodes and days with asthma were associated with increased FeNO values during the study (p < 0.05 for all). Age, atopy and disease activity were found to be important FeNO determinants in preschool children. Longitudinal and individualized FeNO assessment may be valuable in monitoring asthmatic children with recurrent wheezing or mild asthma. MDPI 2020-01-09 /pmc/articles/PMC7020050/ /pubmed/31936693 http://dx.doi.org/10.3390/jcm9010187 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xepapadaki, Paraskevi
Korovessi, Paraskevi
Bachert, Claus
Finotto, Susetta
Jartti, Tuomas
Lakoumentas, John
Kowalski, Marek L.
Lewandowska-Polak, Anna
Lukkarinen, Heikki
Zhang, Nan
Zimmermann, Theodor
Papadopoulos, Nikolaos G.
Evolution of Airway Inflammation in Preschoolers with Asthma—Results of a Two-Year Longitudinal Study
title Evolution of Airway Inflammation in Preschoolers with Asthma—Results of a Two-Year Longitudinal Study
title_full Evolution of Airway Inflammation in Preschoolers with Asthma—Results of a Two-Year Longitudinal Study
title_fullStr Evolution of Airway Inflammation in Preschoolers with Asthma—Results of a Two-Year Longitudinal Study
title_full_unstemmed Evolution of Airway Inflammation in Preschoolers with Asthma—Results of a Two-Year Longitudinal Study
title_short Evolution of Airway Inflammation in Preschoolers with Asthma—Results of a Two-Year Longitudinal Study
title_sort evolution of airway inflammation in preschoolers with asthma—results of a two-year longitudinal study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020050/
https://www.ncbi.nlm.nih.gov/pubmed/31936693
http://dx.doi.org/10.3390/jcm9010187
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