Cargando…

Human Cord Blood Serum-Derived APP α-Secretase Cleavage Activity is Mediated by C1 Complement

Alzheimer’s Disease (AD) is the leading cause of dementia in the elderly. In healthy individuals, amyloid precursor protein (APP) is cleaved by α-secretase, generating soluble α-amyloid precursor protein (sAPPα), which contributes neuroprotective functions in the neuronal environment. In contrast, i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Habib, Ahsan, Sawmiller, Darrell, Hou, Huayan, Kanithi, Manasa, Tian, Jun, Zeng, Jin, Zi, Dan, He, Zhi-Xu, Sanberg, Paul R., Tan, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2018
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020233/ https://www.ncbi.nlm.nih.gov/pubmed/29871524 http://dx.doi.org/10.1177/0963689718775941

Ejemplares similares

Human Umbilical Cord Blood Serum–derived α-Secretase: Functional Testing in Alzheimer’s Disease Mouse Models
por: Habib, Ahsan, et al.
Publicado: (2018)

Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer’s mice
por: Li, Song, et al.
Publicado: (2015)

Specific antibody binding to the APP(672–699) region shifts APP processing from α- to β-cleavage
por: Li, S, et al.
Publicado: (2014)

γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP)
por: Lessard, Christian B., et al.
Publicado: (2015)

γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not
por: Lessard, Christian B., et al.
Publicado: (2020)

Acetylcholinesterase blocks cleavage of APP by γ-secretase in 293 cells and mouse brain
por: Niu, Xin, et al.
Publicado: (2012)

Octyl Gallate Markedly Promotes Anti-Amyloidogenic Processing of APP through Estrogen Receptor-Mediated ADAM10 Activation
por: Zhang, She-Qing, et al.
Publicado: (2013)

Beneficial effects of a pyrroloquinolinequinone-containing dietary formulation on motor deficiency, cognitive decline and mitochondrial dysfunction in a mouse model of Alzheimer’s disease
por: Sawmiller, Darrell, et al.
Publicado: (2017)

APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression
por: Grimm, Marcus O. W., et al.
Publicado: (2015)

Mechanism of Intramembrane Cleavage of Alcadeins by γ-Secretase
por: Piao, Yi, et al.
Publicado: (2013)

GFAP expression and social deficits in transgenic mice overexpressing human sAPPα
por: Bailey, Antoinette R, et al.
Publicado: (2013)

TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production
por: Wang, Junfeng, et al.
Publicado: (2015)

Mucin-Type O-Glycosylation Proximal to β-Secretase Cleavage Site Affects APP Processing and Aggregation Fate
por: Singh, YashoNandini, et al.
Publicado: (2022)

Preferential Regulation of Γ‐Secretase‐Mediated Cleavage of APP by Ganglioside GM1 Reveals a Potential Therapeutic Target for Alzheimer's Disease
por: Wang, Xiaotong, et al.
Publicado: (2023)

LISPRO mitigates β-amyloid and associated pathologies in Alzheimer’s mice
por: Habib, Ahsan, et al.
Publicado: (2017)

Retraction Note to: LISPRO mitigates β-amyloid and associated pathologies in Alzheimer’s mice
por: Habib, Ahsan, et al.
Publicado: (2021)

Baicalein reduces β-amyloid and promotes nonamyloidogenic amyloid precursor protein processing in an Alzheimer’s disease transgenic mouse model
por: Zhang, She-Qing, et al.
Publicado: (2013)

Beneficial Effect of Antibodies against β- Secretase Cleavage Site of App on Alzheimer’s-Like Pathology in Triple-Transgenic Mice
por: Rabinovich-Nikitin, Inna, et al.
Publicado: (2012)

TMP21 Transmembrane Domain Regulates γ-Secretase Cleavage
por: Pardossi-Piquard, Raphaëlle, et al.
Publicado: (2009)

The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase
por: Bolduc, David M, et al.
Publicado: (2016)

Interactions between APP secretases and inflammatory mediators
por: Sastre, Magdalena, et al.
Publicado: (2008)

α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP
por: Roberts, Hazel L., et al.
Publicado: (2017)

Monoubiquitination and endocytosis direct γ-secretase cleavage of activated Notch receptor
por: Gupta-Rossi, Neetu, et al.
Publicado: (2004)

The Metalloprotease Meprin β Is an Alternative β-Secretase of APP
por: Becker-Pauly, Christoph, et al.
Publicado: (2017)

γ-Secretase and Presenilin Mediate Cleavage and Phosphorylation of Vascular Endothelial Growth Factor Receptor-1
por: Cai, Jun, et al.
Publicado: (2011)

The role of heparan sulfate deficiency in autistic phenotype: potential involvement of Slit/Robo/srGAPs-mediated dendritic spine formation
por: Pérez, Christine, et al.
Publicado: (2016)

The neuronal-specific isoform of BIN1 regulates β-secretase cleavage of APP and Aβ generation in a RIN3-dependent manner
por: Bhattacharyya, Raja, et al.
Publicado: (2022)

Caspr1 Facilitates sAPPα Production by Regulating α-Secretase ADAM9 in Brain Endothelial Cells
por: Tang, Shi-Yu, et al.
Publicado: (2020)

Neuroprotective Effect of Ligustilide through Induction of α-Secretase Processing of Both APP and Klotho in a Mouse Model of Alzheimer’s Disease
por: Kuang, Xi, et al.
Publicado: (2017)

Luteolin Reduces Alzheimer’s Disease Pathologies Induced by Traumatic Brain Injury
por: Sawmiller, Darrell, et al.
Publicado: (2014)

Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors
por: Kegel, Kimberly B, et al.
Publicado: (2010)

The aminosterol Claramine inhibits β-secretase 1–mediated insulin receptor cleavage
por: Gaborit, Bénédicte, et al.
Publicado: (2021)

Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer’s disease
por: Kang, Seong Su, et al.
Publicado: (2020)

CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage
por: Sun, Jichao, et al.
Publicado: (2019)

Genome-wide screen of gamma-secretase–mediated intramembrane cleavage of receptor tyrosine kinases
por: Merilahti, Johannes A. M., et al.
Publicado: (2017)

Enzyme–substrate interface targeting by imidazole‐based γ‐secretase modulators activates γ‐secretase and stabilizes its interaction with APP
por: Petit, Dieter, et al.
Publicado: (2022)

Author Correction: The neuronal-specific isoform of BIN1 regulates β-secretase cleavage of APP and Aβ generation in a RIN3-dependent manner
por: Bhattacharyya, Raja, et al.
Publicado: (2022)

Modulation of amyloid precursor protein cleavage by γ-secretase activating protein through phase separation
por: Jin, Chen, et al.
Publicado: (2022)

Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin
por: Schmidt, Fabian C., et al.
Publicado: (2023)

Therapeutic Cocktail Approach for Treatment of Hyperhomocysteinemia in Alzheimer’s Disease
por: Leon, Michael, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_v3peim49vcadp1kp95t7snpcvq