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The eEF2 kinase-induced STAT3 inactivation inhibits lung cancer cell proliferation by phosphorylation of PKM2

BACKGROUND: Eukaryotic elongation factor-2 kinase (eEF2K) is a Ca 2+ /calmodulin (CaM)-dependent protein kinase that inhibits protein synthesis. However, the role of eEF2K in cancer development was reported paradoxically and remains to be elucidated. METHODS: Herein, A549 cells with eEF2K depletion...

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Detalles Bibliográficos
Autores principales:	Xiao, Min, Xie, Jianling, Wu, Yu, Wang, Genzhu, Qi, Xin, Liu, Zailiang, Wang, Yuying, Wang, Xuemin, Hoque, Ashfaqul, Oakhill, Jon, Proud, Christopher G., Li, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020344/ https://www.ncbi.nlm.nih.gov/pubmed/32054489 http://dx.doi.org/10.1186/s12964-020-0528-y

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