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Characteristics and treatment results of recurrence in adult-type granulosa cell tumor of ovary

BACKGROUND: The aim of this study was to explore the clinicopathological characteristics of recurrent adult-type granulosa cell tumor of the ovary (AGCOT) and evaluated the treatment results to define the prognostic parameters for survival after recurrence. RESULTS: A retrospective review of 40 pati...

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Autores principales: Zhao, Dan, Zhang, Yanan, Ou, Zhengjie, Zhang, Rong, Zheng, Shan, Li, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020364/
https://www.ncbi.nlm.nih.gov/pubmed/32059683
http://dx.doi.org/10.1186/s13048-020-00619-6
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author Zhao, Dan
Zhang, Yanan
Ou, Zhengjie
Zhang, Rong
Zheng, Shan
Li, Bin
author_facet Zhao, Dan
Zhang, Yanan
Ou, Zhengjie
Zhang, Rong
Zheng, Shan
Li, Bin
author_sort Zhao, Dan
collection PubMed
description BACKGROUND: The aim of this study was to explore the clinicopathological characteristics of recurrent adult-type granulosa cell tumor of the ovary (AGCOT) and evaluated the treatment results to define the prognostic parameters for survival after recurrence. RESULTS: A retrospective review of 40 patients with recurrent AGCOT, who were treated in the Cancer Hospital at the Chinese Academy of Medical Sciences from 2000 to 2015 was conducted. The impact of clinical and pathological characteristics, progression-free survival (PFS), and post-recurrence therapeutic approaches on prognosis were analyzed. Among the 40 recurrent patients, there were 10 cases where the relapse was uncontrolled, 24 cases had second relapses, and 6 cases without further relapses at the time of our follow-up. The median PFS was 61 months (range, 7-408 months), and the median time interval between the first and the second relapses (R-PFS) was 25 months (range, 0–94 months). The median time interval between the first relapse and death (R-OS) was 90 months (range, 2–216 months). PFS ≥ 61 months (P = 0.004) and post-recurrence therapeutic approach (P < 0.001) were independent risk factors for repeated recurrences. The age at recurrence (P = 0.031) and post-recurrence therapeutic approach (P = 0.001) were independent risk factors for death after recurrence. CONCLUSION: Among patients with recurrent AGCOT, those with long PFS had good prognoses. Maximal cytoreductive effort should be made after recurrence. Complete resection and postoperative adjuvant chemotherapy may improve the prognosis of patients with recurrent AGCOT.
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spelling pubmed-70203642020-02-20 Characteristics and treatment results of recurrence in adult-type granulosa cell tumor of ovary Zhao, Dan Zhang, Yanan Ou, Zhengjie Zhang, Rong Zheng, Shan Li, Bin J Ovarian Res Research BACKGROUND: The aim of this study was to explore the clinicopathological characteristics of recurrent adult-type granulosa cell tumor of the ovary (AGCOT) and evaluated the treatment results to define the prognostic parameters for survival after recurrence. RESULTS: A retrospective review of 40 patients with recurrent AGCOT, who were treated in the Cancer Hospital at the Chinese Academy of Medical Sciences from 2000 to 2015 was conducted. The impact of clinical and pathological characteristics, progression-free survival (PFS), and post-recurrence therapeutic approaches on prognosis were analyzed. Among the 40 recurrent patients, there were 10 cases where the relapse was uncontrolled, 24 cases had second relapses, and 6 cases without further relapses at the time of our follow-up. The median PFS was 61 months (range, 7-408 months), and the median time interval between the first and the second relapses (R-PFS) was 25 months (range, 0–94 months). The median time interval between the first relapse and death (R-OS) was 90 months (range, 2–216 months). PFS ≥ 61 months (P = 0.004) and post-recurrence therapeutic approach (P < 0.001) were independent risk factors for repeated recurrences. The age at recurrence (P = 0.031) and post-recurrence therapeutic approach (P = 0.001) were independent risk factors for death after recurrence. CONCLUSION: Among patients with recurrent AGCOT, those with long PFS had good prognoses. Maximal cytoreductive effort should be made after recurrence. Complete resection and postoperative adjuvant chemotherapy may improve the prognosis of patients with recurrent AGCOT. BioMed Central 2020-02-14 /pmc/articles/PMC7020364/ /pubmed/32059683 http://dx.doi.org/10.1186/s13048-020-00619-6 Text en © The Author(s) 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Zhao, Dan
Zhang, Yanan
Ou, Zhengjie
Zhang, Rong
Zheng, Shan
Li, Bin
Characteristics and treatment results of recurrence in adult-type granulosa cell tumor of ovary
title Characteristics and treatment results of recurrence in adult-type granulosa cell tumor of ovary
title_full Characteristics and treatment results of recurrence in adult-type granulosa cell tumor of ovary
title_fullStr Characteristics and treatment results of recurrence in adult-type granulosa cell tumor of ovary
title_full_unstemmed Characteristics and treatment results of recurrence in adult-type granulosa cell tumor of ovary
title_short Characteristics and treatment results of recurrence in adult-type granulosa cell tumor of ovary
title_sort characteristics and treatment results of recurrence in adult-type granulosa cell tumor of ovary
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020364/
https://www.ncbi.nlm.nih.gov/pubmed/32059683
http://dx.doi.org/10.1186/s13048-020-00619-6
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