Bv8-Like Toxin from the Frog Venom of Amolops jingdongensis Promotes Wound Healing via the Interleukin-1 Signaling Pathway

Prokineticins are highly conserved small peptides family expressed in all vertebrates, which contain a wide spectrum of functions. In this study, a prokineticin homolog (Bv8-AJ) isolated from the venom of frog Amolops jingdongensis was fully characterized. Bv8-AJ accelerated full-thickness wounds he...

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Detalles Bibliográficos
Autores principales: Chang, Jiajia, He, Xiaoqin, Hu, Jingmei, Kamau, Peter Muiruri, Lai, Ren, Rao, Dingqi, Luo, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020442/
https://www.ncbi.nlm.nih.gov/pubmed/31905801
http://dx.doi.org/10.3390/toxins12010015
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author Chang, Jiajia
He, Xiaoqin
Hu, Jingmei
Kamau, Peter Muiruri
Lai, Ren
Rao, Dingqi
Luo, Lei
author_facet Chang, Jiajia
He, Xiaoqin
Hu, Jingmei
Kamau, Peter Muiruri
Lai, Ren
Rao, Dingqi
Luo, Lei
author_sort Chang, Jiajia
collection PubMed
description Prokineticins are highly conserved small peptides family expressed in all vertebrates, which contain a wide spectrum of functions. In this study, a prokineticin homolog (Bv8-AJ) isolated from the venom of frog Amolops jingdongensis was fully characterized. Bv8-AJ accelerated full-thickness wounds healing of mice model by promoting the initiation and the termination of inflammatory phase. Moreover, Bv8-AJ exerted strong proliferative effect on fibroblasts and keratinocytes isolated from newborn mice by activating interleukin (IL)-1 production. Our findings indicate that Bv8 is a potent wound healing regulator and may reveal the mechanism of rapid wound-healing in amphibian skins.
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spelling pubmed-70204422020-03-09 Bv8-Like Toxin from the Frog Venom of Amolops jingdongensis Promotes Wound Healing via the Interleukin-1 Signaling Pathway Chang, Jiajia He, Xiaoqin Hu, Jingmei Kamau, Peter Muiruri Lai, Ren Rao, Dingqi Luo, Lei Toxins (Basel) Article Prokineticins are highly conserved small peptides family expressed in all vertebrates, which contain a wide spectrum of functions. In this study, a prokineticin homolog (Bv8-AJ) isolated from the venom of frog Amolops jingdongensis was fully characterized. Bv8-AJ accelerated full-thickness wounds healing of mice model by promoting the initiation and the termination of inflammatory phase. Moreover, Bv8-AJ exerted strong proliferative effect on fibroblasts and keratinocytes isolated from newborn mice by activating interleukin (IL)-1 production. Our findings indicate that Bv8 is a potent wound healing regulator and may reveal the mechanism of rapid wound-healing in amphibian skins. MDPI 2019-12-29 /pmc/articles/PMC7020442/ /pubmed/31905801 http://dx.doi.org/10.3390/toxins12010015 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chang, Jiajia
He, Xiaoqin
Hu, Jingmei
Kamau, Peter Muiruri
Lai, Ren
Rao, Dingqi
Luo, Lei
Bv8-Like Toxin from the Frog Venom of Amolops jingdongensis Promotes Wound Healing via the Interleukin-1 Signaling Pathway
title Bv8-Like Toxin from the Frog Venom of Amolops jingdongensis Promotes Wound Healing via the Interleukin-1 Signaling Pathway
title_full Bv8-Like Toxin from the Frog Venom of Amolops jingdongensis Promotes Wound Healing via the Interleukin-1 Signaling Pathway
title_fullStr Bv8-Like Toxin from the Frog Venom of Amolops jingdongensis Promotes Wound Healing via the Interleukin-1 Signaling Pathway
title_full_unstemmed Bv8-Like Toxin from the Frog Venom of Amolops jingdongensis Promotes Wound Healing via the Interleukin-1 Signaling Pathway
title_short Bv8-Like Toxin from the Frog Venom of Amolops jingdongensis Promotes Wound Healing via the Interleukin-1 Signaling Pathway
title_sort bv8-like toxin from the frog venom of amolops jingdongensis promotes wound healing via the interleukin-1 signaling pathway
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020442/
https://www.ncbi.nlm.nih.gov/pubmed/31905801
http://dx.doi.org/10.3390/toxins12010015
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