Downregulation of Siah1 promotes colorectal cancer cell proliferation and migration by regulating AKT and YAP ubiquitylation and proteasome degradation

BACKGROUND: Colorectal cancer (CRC) is one of the most common malignant tumors in the world. Siah E3 ubiquitin protein ligase 1 (Siah1) has been identified as a tumor suppressor gene and plays an important role in the development of malignant tumors. However, the potential role and molecular mechani...

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Detalles Bibliográficos
Autores principales: Xiao, Zhiyuan, Wei, Zhigang, Deng, Danling, Zheng, Zhe, Zhao, Yali, Jiang, Shenglu, Zhang, Dan, Zhang, Ling-Jie, Fan, Mingmei, Chen, Siqi, Wang, ShuYang, Ding, Yanqing, Ye, Yaping, Jiao, Hongli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020597/
https://www.ncbi.nlm.nih.gov/pubmed/32082080
http://dx.doi.org/10.1186/s12935-020-1124-3

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