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Bradycardic and Antiarrhythmic Effects of the D-Limonene in Rats

BACKGROUND: D-limonene (DL) is a monoterpene and is the major component in the essential oil of citrus fruit. It presents antihyperglycemic and vasodilatation activities. OBJECTIVES: This study evaluated the cardiovascular effects and potential antiarrhythmic of DL in rats. METHODS: Hemodynamic and...

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Autores principales: do Nascimento, Gildenisson Araújo, de Souza, Diego Santos, Lima, Bruno Santos, de Vasconcelos, Carla Maria Lins, Araújo, Adriano Antunes de Souza, Durço, Aimée Obolari, Quintans-Junior, Lucindo José, Almeida, Jackson Roberto Guedes da Silva, Oliveira, Aldeída Pereira, de Santana-Filho, Valter Joviniano, Barreto, André Sales, dos Santos, Márcio Roberto Viana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Cardiologia - SBC 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020959/
https://www.ncbi.nlm.nih.gov/pubmed/31482987
http://dx.doi.org/10.5935/abc.20190173
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author do Nascimento, Gildenisson Araújo
de Souza, Diego Santos
Lima, Bruno Santos
de Vasconcelos, Carla Maria Lins
Araújo, Adriano Antunes de Souza
Durço, Aimée Obolari
Quintans-Junior, Lucindo José
Almeida, Jackson Roberto Guedes da Silva
Oliveira, Aldeída Pereira
de Santana-Filho, Valter Joviniano
Barreto, André Sales
dos Santos, Márcio Roberto Viana
author_facet do Nascimento, Gildenisson Araújo
de Souza, Diego Santos
Lima, Bruno Santos
de Vasconcelos, Carla Maria Lins
Araújo, Adriano Antunes de Souza
Durço, Aimée Obolari
Quintans-Junior, Lucindo José
Almeida, Jackson Roberto Guedes da Silva
Oliveira, Aldeída Pereira
de Santana-Filho, Valter Joviniano
Barreto, André Sales
dos Santos, Márcio Roberto Viana
author_sort do Nascimento, Gildenisson Araújo
collection PubMed
description BACKGROUND: D-limonene (DL) is a monoterpene and is the major component in the essential oil of citrus fruit. It presents antihyperglycemic and vasodilatation activities. OBJECTIVES: This study evaluated the cardiovascular effects and potential antiarrhythmic of DL in rats. METHODS: Hemodynamic and electrocardiographic (ECG) parameters were measured in male Wistar rats, which under anesthesia had been cannulated in the abdominal aorta and lower vena cava and had electrodes subcutaneously implanted. In the in vitro approach, the heart was removed and perfused using the Langendorff technique. The significance level adopted was 5% (p < 0.05). RESULTS: DL, in doses of 10, 20, and 40 mg/kg (i.v), produced intense and persistent bradycardia associated with hypotension. Bradycardia with prolonged QTc was observed in the ECG in vivo recording. In the in vivo model of arrhythmia induced by Bay K8644, DL (10 mg/kg) decreased the arrhythmia score from 15.33 ± 3.52 to 4.0 ± 2.64 u.a (p < 0.05, n = 4). In isolated perfused hearts, DL (10(-3) M) promoted significant reductions in heart rate (from 228.6 ± 8.5 ms to 196.0 ± 9.3 bpm; p < 0.05) and left ventricular development pressure (from 25.2 ± 3.4 to 5.9 ± 1.8 mmHg; n = 5, p < 0.05). CONCLUSIONS: DL produces bradycardia and antiarrhythmic activity in rat heart.
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spelling pubmed-70209592020-02-20 Bradycardic and Antiarrhythmic Effects of the D-Limonene in Rats do Nascimento, Gildenisson Araújo de Souza, Diego Santos Lima, Bruno Santos de Vasconcelos, Carla Maria Lins Araújo, Adriano Antunes de Souza Durço, Aimée Obolari Quintans-Junior, Lucindo José Almeida, Jackson Roberto Guedes da Silva Oliveira, Aldeída Pereira de Santana-Filho, Valter Joviniano Barreto, André Sales dos Santos, Márcio Roberto Viana Arq Bras Cardiol Original Article BACKGROUND: D-limonene (DL) is a monoterpene and is the major component in the essential oil of citrus fruit. It presents antihyperglycemic and vasodilatation activities. OBJECTIVES: This study evaluated the cardiovascular effects and potential antiarrhythmic of DL in rats. METHODS: Hemodynamic and electrocardiographic (ECG) parameters were measured in male Wistar rats, which under anesthesia had been cannulated in the abdominal aorta and lower vena cava and had electrodes subcutaneously implanted. In the in vitro approach, the heart was removed and perfused using the Langendorff technique. The significance level adopted was 5% (p < 0.05). RESULTS: DL, in doses of 10, 20, and 40 mg/kg (i.v), produced intense and persistent bradycardia associated with hypotension. Bradycardia with prolonged QTc was observed in the ECG in vivo recording. In the in vivo model of arrhythmia induced by Bay K8644, DL (10 mg/kg) decreased the arrhythmia score from 15.33 ± 3.52 to 4.0 ± 2.64 u.a (p < 0.05, n = 4). In isolated perfused hearts, DL (10(-3) M) promoted significant reductions in heart rate (from 228.6 ± 8.5 ms to 196.0 ± 9.3 bpm; p < 0.05) and left ventricular development pressure (from 25.2 ± 3.4 to 5.9 ± 1.8 mmHg; n = 5, p < 0.05). CONCLUSIONS: DL produces bradycardia and antiarrhythmic activity in rat heart. Sociedade Brasileira de Cardiologia - SBC 2019-11 /pmc/articles/PMC7020959/ /pubmed/31482987 http://dx.doi.org/10.5935/abc.20190173 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
spellingShingle Original Article
do Nascimento, Gildenisson Araújo
de Souza, Diego Santos
Lima, Bruno Santos
de Vasconcelos, Carla Maria Lins
Araújo, Adriano Antunes de Souza
Durço, Aimée Obolari
Quintans-Junior, Lucindo José
Almeida, Jackson Roberto Guedes da Silva
Oliveira, Aldeída Pereira
de Santana-Filho, Valter Joviniano
Barreto, André Sales
dos Santos, Márcio Roberto Viana
Bradycardic and Antiarrhythmic Effects of the D-Limonene in Rats
title Bradycardic and Antiarrhythmic Effects of the D-Limonene in Rats
title_full Bradycardic and Antiarrhythmic Effects of the D-Limonene in Rats
title_fullStr Bradycardic and Antiarrhythmic Effects of the D-Limonene in Rats
title_full_unstemmed Bradycardic and Antiarrhythmic Effects of the D-Limonene in Rats
title_short Bradycardic and Antiarrhythmic Effects of the D-Limonene in Rats
title_sort bradycardic and antiarrhythmic effects of the d-limonene in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020959/
https://www.ncbi.nlm.nih.gov/pubmed/31482987
http://dx.doi.org/10.5935/abc.20190173
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