Cargando…

Shifting from fear to safety through deconditioning-update

Aversive memories are at the heart of psychiatric disorders such as phobias and post-traumatic stress disorder (PTSD). Here, we present a new behavioral approach in rats that robustly attenuates aversive memories. This method consists of ‘deconditioning’ animals previously trained to associate a ton...

Descripción completa

Detalles Bibliográficos
Autores principales:	Popik, Bruno, Amorim, Felippe Espinelli, Amaral, Olavo B, De Oliveira Alvares, Lucas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021486/ https://www.ncbi.nlm.nih.gov/pubmed/31999254 http://dx.doi.org/10.7554/eLife.51207

Ejemplares similares

A Freely Available, Self-Calibrating Software for Automatic Measurement of Freezing Behavior
por: Amorim, Felippe E., et al.
Publicado: (2019)

Different temporal windows for CB1 receptor involvement in contextual fear memory destabilisation in the amygdala and hippocampus
por: Lee, Jonathan L. C., et al.
Publicado: (2019)

Artificial gravity as a countermeasure for mitigating physiological deconditioning during long-duration space missions
por: Clément, Gilles R., et al.
Publicado: (2015)

Cardiovascular deconditioning during long-term spaceflight through multiscale modeling
por: Gallo, Caterina, et al.
Publicado: (2020)

Reduced Expression of Hippocampal GluN2A-NMDAR Increases Seizure Susceptibility and Causes Deficits in Contextual Memory
por: Acutain, Maria Florencia, et al.
Publicado: (2021)

Plasticity of Fear and Safety Neurons of the Amygdala in Response to Fear Extinction
por: Sangha, Susan
Publicado: (2015)

Long COVID: Distinction between Organ Damage and Deconditioning
por: Kersten, Johannes, et al.
Publicado: (2021)

Hospital‐associated deconditioning: Not only physical, but also cognitive
por: Chen, Yaohua, et al.
Publicado: (2022)

Estimation of Functional Reserve in Patients with Hospital-Associated Deconditioning
por: Kim, Minhee, et al.
Publicado: (2022)

The Deconditioning Effect of the COVID-19 Pandemic on Unaffected Healthy Children
por: Dayton, Jeffrey D., et al.
Publicado: (2021)

Elevated biomarkers of neural injury in older adults following head-down bed rest: links to cardio-postural deconditioning with spaceflight and aging
por: Blaber, Andrew P., et al.
Publicado: (2023)

Mechanisms of exercise intolerance after COVID-19: new perspectives beyond physical deconditioning
por: Ferreira, Eloara Vieira Machado, et al.
Publicado: (2021)

Physical Deconditioning as a Cause of Breathlessness among Obese Adolescents with a Diagnosis of Asthma
por: Shim, Yun M., et al.
Publicado: (2013)

Safety, Feasibility and Efficacy of Lokomat(®) and Armeo(®)Spring Training in Deconditioned Paediatric, Adolescent and Young Adult Cancer Patients
por: Atkinson, Morgan, et al.
Publicado: (2023)

Impact of deconditioning on the secondary electron yield of Cu surfaces in particle accelerators
por: Petit, V, et al.
Publicado: (2020)

Artificial Gravity as a Countermeasure to the Cardiovascular Deconditioning of Spaceflight: Gender Perspectives
por: Evans, Joyce M., et al.
Publicado: (2018)

Deconditioning as main mechanism of impaired exercise response in COVID-19 survivors
por: Rinaldo, Rocco Francesco, et al.
Publicado: (2021)

The musculoskeletal implications of deconditioning in older adults during and following COVID-19
por: Santy-Tomlinson, Julie
Publicado: (2021)

An Exercise Mimetic Approach to Reduce Poststroke Deconditioning and Enhance Stroke Recovery
por: McDonald, Matthew W., et al.
Publicado: (2021)

Metabolomics as an Important Tool for Determining the Mechanisms of Human Skeletal Muscle Deconditioning
por: Alldritt, Isabelle, et al.
Publicado: (2021)

ABL1 in thalamus is associated with safety but not fear learning
por: Habib, Mouna R., et al.
Publicado: (2013)

Multi-System Deconditioning in 3-Day Dry Immersion without Daily Raise
por: De Abreu, Steven, et al.
Publicado: (2017)

Memory destabilization during reconsolidation: a consequence of homeostatic plasticity?
por: Amorim, Felippe E., et al.
Publicado: (2021)

Enhancement of fear memory by retrieval through reconsolidation
por: Fukushima, Hotaka, et al.
Publicado: (2014)

On the transition from reconsolidation to extinction of contextual fear memories
por: Cassini, Lindsey F., et al.
Publicado: (2017)

Update on neurobiological mechanisms of fear: illuminating the direction of mechanism exploration and treatment development of trauma and fear-related disorders
por: Li, Ying, et al.
Publicado: (2023)

Heightened fear in response to a safety cue and extinguished fear cue in a rat model of maternal immune activation
por: Sangha, Susan, et al.
Publicado: (2014)

Are fear memories erasable?–reconsolidation of learned fear with fear-relevant and fear-irrelevant stimuli
por: Golkar, Armita, et al.
Publicado: (2012)

Are persons with rheumatoid arthritis deconditioned? A review of physical activity and aerobic capacity
por: Munsterman, Tjerk, et al.
Publicado: (2012)

A qualitative study exploring the lived experiences of deconditioning in hospital in Ontario, Canada
por: Guilcher, Sara J. T., et al.
Publicado: (2021)

Early Deconditioning of Human Skeletal Muscles and the Effects of a Thigh Cuff Countermeasure
por: Fovet, Théo, et al.
Publicado: (2021)

Exercise capacity impairment after COVID-19 pneumonia is mainly caused by deconditioning
por: Jahn, Kathleen, et al.
Publicado: (2022)

NPY Released From GABA Neurons of the Dentate Gyrus Specially Reduces Contextual Fear Without Affecting Cued or Trace Fear
por: Comeras, Lucas B., et al.
Publicado: (2021)

A Custom Microcontrolled and Wireless-Operated Chamber for Auditory Fear Conditioning
por: Amaral-Júnior, Paulo Aparecido, et al.
Publicado: (2019)

Altered fear engram encoding underlying conditioned versus unconditioned stimulus–initiated memory updating
por: Teng, Shuai-Wen, et al.
Publicado: (2023)

Fear extinction relies on ventral hippocampal safety codes shaped by the amygdala
por: Nguyen, Robin, et al.
Publicado: (2023)

A Moderate Daily Dose of Resveratrol Mitigates Muscle Deconditioning in a Martian Gravity Analog
por: Mortreux, Marie, et al.
Publicado: (2019)

Brain-wide screen of prelimbic cortex inputs reveals a functional shift during early fear memory consolidation
por: Dixsaut, Lucie, et al.
Publicado: (2022)

Sex Differences in Remote Contextual Fear Generalization in Mice
por: Asok, Arun, et al.
Publicado: (2019)

High-Intensity Exercise Mitigates Cardiovascular Deconditioning During Long-Duration Bed Rest
por: Maggioni, Martina A., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_35qq9dnt7h74rhdrr2qh3jbtlf