Tobacco exposure and somatic mutations in normal human bronchial epithelium

Tobacco smoking causes lung cancer(1–3), driven by the 60+ carcinogens in cigarette smoke that directly damage and mutate DNA(4,5). The profound effects of tobacco on the lung cancer genome have been well documented(6–10), but we lack equivalent data for normal bronchial cells. We sequenced whole ge...

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Detalles Bibliográficos
Autores principales: Yoshida, Kenichi, Gowers, Kate HC, Lee-Six, Henry, Chandrasekharan, Deepak P, Coorens, Tim, Maughan, Elizabeth F, Beal, Kathryn, Menzies, Andrew, Millar, Fraser R, Anderson, Elizabeth, Clarke, Sarah E, Pennycuick, Adam, Thakrar, Ricky M, Butler, Colin R, Kakiuchi, Nobuyuki, Hirano, Tomonori, Hynds, Robert E, Stratton, Michael R, Martincorena, Inigo, Janes, Sam M, Campbell, Peter J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021511/
https://www.ncbi.nlm.nih.gov/pubmed/31996850
http://dx.doi.org/10.1038/s41586-020-1961-1

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