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Conformational sampling and kinetics changes across a non-Arrhenius break point in the enzyme thermolysin
Numerous studies have suggested a significant role that protein dynamics play in optimizing enzyme catalysis, and changes in conformational sampling offer a window to explore this role. Thermolysin from Bacillus thermoproteolyticus rokko, which is a heat-stable zinc metalloproteinase, serves here as...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Crystallographic Association
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021514/ https://www.ncbi.nlm.nih.gov/pubmed/32095489 http://dx.doi.org/10.1063/1.5130582 |