Dual Feedforward Loops Modulate Type I Interferon Responses and Induce Selective Gene Expression during TLR4 Activation

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Although the dynamic features of type I coherent feedforward loop (C1-FFL) has been well studied, how C1-FFL shapes cell-to-cell heterogeneity remains unclear. Here, we found that C1-FFL with OR logic serves as “noise reducer,” whereas C1-FFL with AND logic functions as “noise propagator” to fine-tu...

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Detalles Bibliográficos
Autores principales: Zhou, Jie, Sun, Tingzhe, Jin, Shouheng, Guo, Zhiyong, Cui, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021547/
https://www.ncbi.nlm.nih.gov/pubmed/32062450
http://dx.doi.org/10.1016/j.isci.2020.100881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021547/
https://www.ncbi.nlm.nih.gov/pubmed/32062450
http://dx.doi.org/10.1016/j.isci.2020.100881

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