A High-Throughput Method for Characterizing Novel Chimeric Antigen Receptors in Jurkat Cells

Chimeric antigen receptor (CAR) development involves extensive empirical characterization of antigen-binding domain (ABD)/CAR constructs for clinical suitability. Here, we present a cost-efficient and rapid method for evaluating CARs in human Jurkat T cells. Using a modular CAR plasmid, a highly eff...

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Detalles Bibliográficos
Autores principales: Bloemberg, Darin, Nguyen, Tina, MacLean, Susanne, Zafer, Ahmed, Gadoury, Christine, Gurnani, Komal, Chattopadhyay, Anindita, Ash, Josée, Lippens, Julie, Harcus, Doreen, Pagé, Martine, Fortin, Annie, Pon, Robert A., Gilbert, Rénald, Marcil, Anne, Weeratna, Risini D., McComb, Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021643/
https://www.ncbi.nlm.nih.gov/pubmed/32083149
http://dx.doi.org/10.1016/j.omtm.2020.01.012

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