Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency

The ATM kinase is a master regulator of the DNA damage response to double-strand breaks (DSBs) and a well-established tumour suppressor whose loss is the cause of the neurodegenerative and cancer-prone syndrome Ataxia-Telangiectasia (A-T). A-T patients and Atm(−/−) mouse models are particularly pred...

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Detalles Bibliográficos
Autores principales: Álvarez-Quilón, Alejandro, Terrón-Bautista, José, Delgado-Sainz, Irene, Serrano-Benítez, Almudena, Romero-Granados, Rocío, Martínez-García, Pedro Manuel, Jimeno-González, Silvia, Bernal-Lozano, Cristina, Quintero, Cristina, García-Quintanilla, Lourdes, Cortés-Ledesma, Felipe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021672/
https://www.ncbi.nlm.nih.gov/pubmed/32060399
http://dx.doi.org/10.1038/s41467-020-14638-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021672/
https://www.ncbi.nlm.nih.gov/pubmed/32060399
http://dx.doi.org/10.1038/s41467-020-14638-w

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