O-GlcNAcylation of PFKFB3 is required for tumor cell proliferation under hypoxia

The protein O-GlcNAcylation catalysed by O-GlcNAc transferase (OGT) is tightly regulated by glucose availability. It is upregulated and essential for tumor cell proliferation under hypoxic conditions. However, the mechanism behind is still unclear. Here, we showed that the glycolytic regulator 6-pho...

Descripción completa

Detalles Bibliográficos
Autores principales: Lei, Yinrui, Chen, Tao, Li, Yeyi, Shang, Man, Zhang, Yan, Jin, Yuepeng, Yu, Qiujing, Guo, Fang, Wang, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021673/
https://www.ncbi.nlm.nih.gov/pubmed/32060258
http://dx.doi.org/10.1038/s41389-020-0208-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021673/
https://www.ncbi.nlm.nih.gov/pubmed/32060258
http://dx.doi.org/10.1038/s41389-020-0208-1

Ejemplares similares