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Interethnic differences in neuroimaging markers and cognition in Asians, a population-based study

We examined interethnic differences in the prevalence of neuroimaging markers of cerebrovascular and neurodegenerative disease in 3 major Asian ethnicities (Chinese, Malays, and Indians), as well as their role in cognitive impairment. 3T MRI brain scans were acquired from 792 subjects (mean age: 70....

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Autores principales: Wong, Louis Choon Kit, Wong, Mark Yu Zheng, Tan, Chuen Seng, Vrooman, Henri, Venketasubramanian, Narayanaswamy, Cheng, Ching-Yu, Chen, Christopher, Hilal, Saima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021682/
https://www.ncbi.nlm.nih.gov/pubmed/32060376
http://dx.doi.org/10.1038/s41598-020-59618-8
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author Wong, Louis Choon Kit
Wong, Mark Yu Zheng
Tan, Chuen Seng
Vrooman, Henri
Venketasubramanian, Narayanaswamy
Cheng, Ching-Yu
Chen, Christopher
Hilal, Saima
author_facet Wong, Louis Choon Kit
Wong, Mark Yu Zheng
Tan, Chuen Seng
Vrooman, Henri
Venketasubramanian, Narayanaswamy
Cheng, Ching-Yu
Chen, Christopher
Hilal, Saima
author_sort Wong, Louis Choon Kit
collection PubMed
description We examined interethnic differences in the prevalence of neuroimaging markers of cerebrovascular and neurodegenerative disease in 3 major Asian ethnicities (Chinese, Malays, and Indians), as well as their role in cognitive impairment. 3T MRI brain scans were acquired from 792 subjects (mean age: 70.0 ± 6.5years, 52.1% women) in the multi-ethnic Epidemiology of Dementia In Singapore study. Markers of cerebrovascular disease and neurodegeneration were identified. Cognitive performance was evaluated using Mini Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and a neuropsychological assessment. Compared to Chinese, Malays had a higher burden of intracranial stenosis (OR: 2.28. 95%CI: 1.23–4.20) and cortical atrophy (β: −0.60. 95%CI: −0.78, −0.41), while Indians had a higher burden of subcortical atrophy (β: −0.23. 95%CI: −0.40, −0.06). Moreover, Malay and Indian ethnicities were likely to be cognitively impaired (OR for Malays: 3.79. 95%CI: 2.29–6.26; OR for Indians: 2.87. 95%CI: 1.74–4.74) and showed worse performance in global cognition (β for Malays: −0.51. 95%CI: −0.66, −0.37; and Indians: −0.32. 95%CI: −0.47, −0.17). A higher burden of cerebrovascular and neurodegenerative markers were found in Malays and Indians when compared to Chinese. Further research is required to fully elucidate the factors and pathways that contribute to these observed differences.
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spelling pubmed-70216822020-02-24 Interethnic differences in neuroimaging markers and cognition in Asians, a population-based study Wong, Louis Choon Kit Wong, Mark Yu Zheng Tan, Chuen Seng Vrooman, Henri Venketasubramanian, Narayanaswamy Cheng, Ching-Yu Chen, Christopher Hilal, Saima Sci Rep Article We examined interethnic differences in the prevalence of neuroimaging markers of cerebrovascular and neurodegenerative disease in 3 major Asian ethnicities (Chinese, Malays, and Indians), as well as their role in cognitive impairment. 3T MRI brain scans were acquired from 792 subjects (mean age: 70.0 ± 6.5years, 52.1% women) in the multi-ethnic Epidemiology of Dementia In Singapore study. Markers of cerebrovascular disease and neurodegeneration were identified. Cognitive performance was evaluated using Mini Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and a neuropsychological assessment. Compared to Chinese, Malays had a higher burden of intracranial stenosis (OR: 2.28. 95%CI: 1.23–4.20) and cortical atrophy (β: −0.60. 95%CI: −0.78, −0.41), while Indians had a higher burden of subcortical atrophy (β: −0.23. 95%CI: −0.40, −0.06). Moreover, Malay and Indian ethnicities were likely to be cognitively impaired (OR for Malays: 3.79. 95%CI: 2.29–6.26; OR for Indians: 2.87. 95%CI: 1.74–4.74) and showed worse performance in global cognition (β for Malays: −0.51. 95%CI: −0.66, −0.37; and Indians: −0.32. 95%CI: −0.47, −0.17). A higher burden of cerebrovascular and neurodegenerative markers were found in Malays and Indians when compared to Chinese. Further research is required to fully elucidate the factors and pathways that contribute to these observed differences. Nature Publishing Group UK 2020-02-14 /pmc/articles/PMC7021682/ /pubmed/32060376 http://dx.doi.org/10.1038/s41598-020-59618-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Wong, Louis Choon Kit
Wong, Mark Yu Zheng
Tan, Chuen Seng
Vrooman, Henri
Venketasubramanian, Narayanaswamy
Cheng, Ching-Yu
Chen, Christopher
Hilal, Saima
Interethnic differences in neuroimaging markers and cognition in Asians, a population-based study
title Interethnic differences in neuroimaging markers and cognition in Asians, a population-based study
title_full Interethnic differences in neuroimaging markers and cognition in Asians, a population-based study
title_fullStr Interethnic differences in neuroimaging markers and cognition in Asians, a population-based study
title_full_unstemmed Interethnic differences in neuroimaging markers and cognition in Asians, a population-based study
title_short Interethnic differences in neuroimaging markers and cognition in Asians, a population-based study
title_sort interethnic differences in neuroimaging markers and cognition in asians, a population-based study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021682/
https://www.ncbi.nlm.nih.gov/pubmed/32060376
http://dx.doi.org/10.1038/s41598-020-59618-8
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