Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis

Copper levels are known to be elevated in inflamed and malignant tissues. But the mechanism underlying this selective enrichment has been elusive. In this study, we report a axis by which inflammatory cytokines, such as IL-17, drive cellular copper uptake via the induction of a metalloreductase, STE...

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Detalles Bibliográficos
Autores principales: Liao, Yun, Zhao, Junjie, Bulek, Katarzyna, Tang, Fangqiang, Chen, Xing, Cai, Gang, Jia, Shang, Fox, Paul L., Huang, Emina, Pizarro, Theresa T., Kalady, Matthew F., Jackson, Mark W., Bao, Shideng, Sen, Ganes C., Stark, George R., Chang, Christopher J., Li, Xiaoxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021685/
https://www.ncbi.nlm.nih.gov/pubmed/32060280
http://dx.doi.org/10.1038/s41467-020-14698-y

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