Mutations in the HPV16 genome induced by APOBEC3 are associated with viral clearance

HPV16 causes half of cervical cancers worldwide; for unknown reasons, most infections resolve within two years. Here, we analyze the viral genomes of 5,328 HPV16-positive case-control samples to investigate mutational signatures and the role of human APOBEC3-induced mutations in viral clearance and...

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Detalles Bibliográficos
Autores principales: Zhu, Bin, Xiao, Yanzi, Yeager, Meredith, Clifford, Gary, Wentzensen, Nicolas, Cullen, Michael, Boland, Joseph F., Bass, Sara, Steinberg, Mia K., Raine-Bennett, Tina, Lee, DongHyuk, Burk, Robert D., Pinheiro, Maisa, Song, Lei, Dean, Michael, Nelson, Chase W., Burdett, Laurie, Yu, Kai, Roberson, David, Lorey, Thomas, Franceschi, Silvia, Castle, Philip E., Walker, Joan, Zuna, Rosemary, Schiffman, Mark, Mirabello, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021686/
https://www.ncbi.nlm.nih.gov/pubmed/32060290
http://dx.doi.org/10.1038/s41467-020-14730-1

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