Schizophrenia-related microdeletion causes defective ciliary motility and brain ventricle enlargement via microRNA-dependent mechanisms in mice

Progressive ventricular enlargement, a key feature of several neurologic and psychiatric diseases, is mediated by unknown mechanisms. Here, using murine models of 22q11-deletion syndrome (22q11DS), which is associated with schizophrenia in humans, we found progressive enlargement of lateral and thir...

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Detalles Bibliográficos
Autores principales: Eom, Tae-Yeon, Han, Seung Baek, Kim, Jieun, Blundon, Jay A., Wang, Yong-Dong, Yu, Jing, Anderson, Kara, Kaminski, Damian B., Sakurada, Sadie Miki, Pruett-Miller, Shondra M., Horner, Linda, Wagner, Ben, Robinson, Camenzind G., Eicholtz, Matthew, Rose, Derek C., Zakharenko, Stanislav S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021727/
https://www.ncbi.nlm.nih.gov/pubmed/32060266
http://dx.doi.org/10.1038/s41467-020-14628-y

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