Modified mRNA/lipid nanoparticle-based vaccines expressing respiratory syncytial virus F protein variants are immunogenic and protective in rodent models of RSV infection

The RSV Fusion (F) protein is a target for neutralizing antibody responses and is a focus for vaccine discovery; however, the process of RSV entry requires F to adopt a metastable prefusion form and transition to a more stable postfusion form, which displays less potent neutralizing epitopes. mRNA v...

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Detalles Bibliográficos
Autores principales: Espeseth, Amy S., Cejas, Pedro J., Citron, Michael P., Wang, Dai, DiStefano, Daniel J., Callahan, Cheryl, Donnell, Gregory O’, Galli, Jennifer D., Swoyer, Ryan, Touch, Sinoeun, Wen, Zhiyun, Antonello, Joseph, Zhang, Lan, Flynn, Jessica A., Cox, Kara S., Freed, Daniel C., Vora, Kalpit A., Bahl, Kapil, Latham, Andrew H., Smith, Jeffrey S., Gindy, Marian E., Ciaramella, Giuseppe, Hazuda, Daria, Shaw, Christine A., Bett, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021756/
https://www.ncbi.nlm.nih.gov/pubmed/32128257
http://dx.doi.org/10.1038/s41541-020-0163-z

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