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Conformational perturbation, allosteric modulation of cellular signaling pathways, and disease in P23H rhodopsin
In this investigation we use THz spectroscopy and MD simulation to study the functional dynamics and conformational stability of P23H rhodopsin. The P23H mutation of rod opsin is the most common cause of human binding autosomal dominant retinitis pigmentosa (ADRP), but the precise mechanism by which...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021821/ https://www.ncbi.nlm.nih.gov/pubmed/32060349 http://dx.doi.org/10.1038/s41598-020-59583-2 |