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Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank

Although snoring is common in the general population, its aetiology has been largely understudied. Here we report a genetic study on snoring (n ~ 408,000; snorers ~ 152,000) using data from the UK Biobank. We identify 42 genome-wide significant loci, with an SNP-based heritability estimate of ~10% o...

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Autores principales: Campos, Adrián I., García-Marín, Luis M., Byrne, Enda M., Martin, Nicholas G., Cuéllar-Partida, Gabriel, Rentería, Miguel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021827/
https://www.ncbi.nlm.nih.gov/pubmed/32060260
http://dx.doi.org/10.1038/s41467-020-14625-1
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author Campos, Adrián I.
García-Marín, Luis M.
Byrne, Enda M.
Martin, Nicholas G.
Cuéllar-Partida, Gabriel
Rentería, Miguel E.
author_facet Campos, Adrián I.
García-Marín, Luis M.
Byrne, Enda M.
Martin, Nicholas G.
Cuéllar-Partida, Gabriel
Rentería, Miguel E.
author_sort Campos, Adrián I.
collection PubMed
description Although snoring is common in the general population, its aetiology has been largely understudied. Here we report a genetic study on snoring (n ~ 408,000; snorers ~ 152,000) using data from the UK Biobank. We identify 42 genome-wide significant loci, with an SNP-based heritability estimate of ~10% on the liability scale. Genetic correlations with body mass index, alcohol intake, smoking, schizophrenia, anorexia nervosa and neuroticism are observed. Gene-based associations identify 173 genes, including DLEU7, MSRB3 and POC5, highlighting genes expressed in the brain, cerebellum, lungs, blood and oesophagus. We use polygenic scores (PGS) to predict recent snoring and probable obstructive sleep apnoea (OSA) in an independent Australian sample (n ~ 8000). Mendelian randomization analyses suggest a potential causal relationship between high BMI and snoring. Altogether, our results uncover insights into the aetiology of snoring as a complex sleep-related trait and its role in health and disease beyond it being a cardinal symptom of OSA.
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spelling pubmed-70218272020-02-21 Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank Campos, Adrián I. García-Marín, Luis M. Byrne, Enda M. Martin, Nicholas G. Cuéllar-Partida, Gabriel Rentería, Miguel E. Nat Commun Article Although snoring is common in the general population, its aetiology has been largely understudied. Here we report a genetic study on snoring (n ~ 408,000; snorers ~ 152,000) using data from the UK Biobank. We identify 42 genome-wide significant loci, with an SNP-based heritability estimate of ~10% on the liability scale. Genetic correlations with body mass index, alcohol intake, smoking, schizophrenia, anorexia nervosa and neuroticism are observed. Gene-based associations identify 173 genes, including DLEU7, MSRB3 and POC5, highlighting genes expressed in the brain, cerebellum, lungs, blood and oesophagus. We use polygenic scores (PGS) to predict recent snoring and probable obstructive sleep apnoea (OSA) in an independent Australian sample (n ~ 8000). Mendelian randomization analyses suggest a potential causal relationship between high BMI and snoring. Altogether, our results uncover insights into the aetiology of snoring as a complex sleep-related trait and its role in health and disease beyond it being a cardinal symptom of OSA. Nature Publishing Group UK 2020-02-14 /pmc/articles/PMC7021827/ /pubmed/32060260 http://dx.doi.org/10.1038/s41467-020-14625-1 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Campos, Adrián I.
García-Marín, Luis M.
Byrne, Enda M.
Martin, Nicholas G.
Cuéllar-Partida, Gabriel
Rentería, Miguel E.
Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank
title Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank
title_full Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank
title_fullStr Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank
title_full_unstemmed Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank
title_short Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank
title_sort insights into the aetiology of snoring from observational and genetic investigations in the uk biobank
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021827/
https://www.ncbi.nlm.nih.gov/pubmed/32060260
http://dx.doi.org/10.1038/s41467-020-14625-1
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