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Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene
A fundamental feature of life is that ribosomes read the genetic code in messenger RNA (mRNA) as triplets of nucleotides in a single reading frame. Mutations that shift the reading frame generally cause gene inactivation and in essential genes cause loss of viability. Here we report and characterize...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022156/ https://www.ncbi.nlm.nih.gov/pubmed/31992637 http://dx.doi.org/10.1073/pnas.1919390117 |