Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2

The spliceosome consists of five small RNAs and more than 100 proteins. Almost 50% of the human spliceosomal proteins were predicted to be intrinsically disordered or to contain disordered regions, among them the G-patch protein Spp2. The G-patch region of Spp2 binds to the DEAH-box ATPase Prp2, and...

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Detalles Bibliográficos
Autores principales: Hamann, Florian, Schmitt, Andreas, Favretto, Filippo, Hofele, Romina, Neumann, Piotr, Xiang, ShengQi, Urlaub, Henning, Zweckstetter, Markus, Ficner, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022188/
https://www.ncbi.nlm.nih.gov/pubmed/31974312
http://dx.doi.org/10.1073/pnas.1907960117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022188/
https://www.ncbi.nlm.nih.gov/pubmed/31974312
http://dx.doi.org/10.1073/pnas.1907960117

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