Cargando…

Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep

SIMPLE SUMMARY: Body weight traits are economically important in the sheep industry, and it is critical to explore their underlying genetic architecture. Hence, four body weight traits, including birth, weaning, yearling, and adult weights were examined. Through a genome-wide association study on Ch...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Zengkui, Yue, Yaojing, Yuan, Chao, Liu, Jianbin, Chen, Zhiqiang, Niu, Chune, Sun, Xiaoping, Zhu, Shaohua, Zhao, Hongchang, Guo, Tingting, Yang, Bohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022301/
https://www.ncbi.nlm.nih.gov/pubmed/31963922
http://dx.doi.org/10.3390/ani10010170
_version_ 1783497991956463616
author Lu, Zengkui
Yue, Yaojing
Yuan, Chao
Liu, Jianbin
Chen, Zhiqiang
Niu, Chune
Sun, Xiaoping
Zhu, Shaohua
Zhao, Hongchang
Guo, Tingting
Yang, Bohui
author_facet Lu, Zengkui
Yue, Yaojing
Yuan, Chao
Liu, Jianbin
Chen, Zhiqiang
Niu, Chune
Sun, Xiaoping
Zhu, Shaohua
Zhao, Hongchang
Guo, Tingting
Yang, Bohui
author_sort Lu, Zengkui
collection PubMed
description SIMPLE SUMMARY: Body weight traits are economically important in the sheep industry, and it is critical to explore their underlying genetic architecture. Hence, four body weight traits, including birth, weaning, yearling, and adult weights were examined. Through a genome-wide association study on Chinese fine-wool sheep, several candidate single-nucleotide polymorphisms (SNPs) and genes were found potentially associated with the traits of interest. The results of this study may facilitate the potential use of the genes involved in growth and production traits for the genetic improvement of productivity in sheep. ABSTRACT: Body weight is an important economic trait for sheep and it is vital for their successful production and breeding. Therefore, identifying the genomic regions and biological pathways that contribute to understanding variability in body weight traits is significant for selection purposes. In this study, the genome-wide associations of birth, weaning, yearling, and adult weights of 460 fine-wool sheep were determined using resequencing technology. The results showed that 113 single nucleotide polymorphisms (SNPs) reached the genome-wide significance levels for the four body weight traits and 30 genes were annotated effectively, including AADACL3, VGF, NPC1, and SERPINA12. The genes annotated by these SNPs significantly enriched 78 gene ontology terms and 25 signaling pathways, and were found to mainly participate in skeletal muscle development and lipid metabolism. These genes can be used as candidate genes for body weight in sheep, and provide useful information for the production and genomic selection of Chinese fine-wool sheep.
format Online
Article
Text
id pubmed-7022301
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-70223012020-03-09 Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep Lu, Zengkui Yue, Yaojing Yuan, Chao Liu, Jianbin Chen, Zhiqiang Niu, Chune Sun, Xiaoping Zhu, Shaohua Zhao, Hongchang Guo, Tingting Yang, Bohui Animals (Basel) Article SIMPLE SUMMARY: Body weight traits are economically important in the sheep industry, and it is critical to explore their underlying genetic architecture. Hence, four body weight traits, including birth, weaning, yearling, and adult weights were examined. Through a genome-wide association study on Chinese fine-wool sheep, several candidate single-nucleotide polymorphisms (SNPs) and genes were found potentially associated with the traits of interest. The results of this study may facilitate the potential use of the genes involved in growth and production traits for the genetic improvement of productivity in sheep. ABSTRACT: Body weight is an important economic trait for sheep and it is vital for their successful production and breeding. Therefore, identifying the genomic regions and biological pathways that contribute to understanding variability in body weight traits is significant for selection purposes. In this study, the genome-wide associations of birth, weaning, yearling, and adult weights of 460 fine-wool sheep were determined using resequencing technology. The results showed that 113 single nucleotide polymorphisms (SNPs) reached the genome-wide significance levels for the four body weight traits and 30 genes were annotated effectively, including AADACL3, VGF, NPC1, and SERPINA12. The genes annotated by these SNPs significantly enriched 78 gene ontology terms and 25 signaling pathways, and were found to mainly participate in skeletal muscle development and lipid metabolism. These genes can be used as candidate genes for body weight in sheep, and provide useful information for the production and genomic selection of Chinese fine-wool sheep. MDPI 2020-01-19 /pmc/articles/PMC7022301/ /pubmed/31963922 http://dx.doi.org/10.3390/ani10010170 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lu, Zengkui
Yue, Yaojing
Yuan, Chao
Liu, Jianbin
Chen, Zhiqiang
Niu, Chune
Sun, Xiaoping
Zhu, Shaohua
Zhao, Hongchang
Guo, Tingting
Yang, Bohui
Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep
title Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep
title_full Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep
title_fullStr Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep
title_full_unstemmed Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep
title_short Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep
title_sort genome-wide association study of body weight traits in chinese fine-wool sheep
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022301/
https://www.ncbi.nlm.nih.gov/pubmed/31963922
http://dx.doi.org/10.3390/ani10010170
work_keys_str_mv AT luzengkui genomewideassociationstudyofbodyweighttraitsinchinesefinewoolsheep
AT yueyaojing genomewideassociationstudyofbodyweighttraitsinchinesefinewoolsheep
AT yuanchao genomewideassociationstudyofbodyweighttraitsinchinesefinewoolsheep
AT liujianbin genomewideassociationstudyofbodyweighttraitsinchinesefinewoolsheep
AT chenzhiqiang genomewideassociationstudyofbodyweighttraitsinchinesefinewoolsheep
AT niuchune genomewideassociationstudyofbodyweighttraitsinchinesefinewoolsheep
AT sunxiaoping genomewideassociationstudyofbodyweighttraitsinchinesefinewoolsheep
AT zhushaohua genomewideassociationstudyofbodyweighttraitsinchinesefinewoolsheep
AT zhaohongchang genomewideassociationstudyofbodyweighttraitsinchinesefinewoolsheep
AT guotingting genomewideassociationstudyofbodyweighttraitsinchinesefinewoolsheep
AT yangbohui genomewideassociationstudyofbodyweighttraitsinchinesefinewoolsheep