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Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep
SIMPLE SUMMARY: Body weight traits are economically important in the sheep industry, and it is critical to explore their underlying genetic architecture. Hence, four body weight traits, including birth, weaning, yearling, and adult weights were examined. Through a genome-wide association study on Ch...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022301/ https://www.ncbi.nlm.nih.gov/pubmed/31963922 http://dx.doi.org/10.3390/ani10010170 |
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author | Lu, Zengkui Yue, Yaojing Yuan, Chao Liu, Jianbin Chen, Zhiqiang Niu, Chune Sun, Xiaoping Zhu, Shaohua Zhao, Hongchang Guo, Tingting Yang, Bohui |
author_facet | Lu, Zengkui Yue, Yaojing Yuan, Chao Liu, Jianbin Chen, Zhiqiang Niu, Chune Sun, Xiaoping Zhu, Shaohua Zhao, Hongchang Guo, Tingting Yang, Bohui |
author_sort | Lu, Zengkui |
collection | PubMed |
description | SIMPLE SUMMARY: Body weight traits are economically important in the sheep industry, and it is critical to explore their underlying genetic architecture. Hence, four body weight traits, including birth, weaning, yearling, and adult weights were examined. Through a genome-wide association study on Chinese fine-wool sheep, several candidate single-nucleotide polymorphisms (SNPs) and genes were found potentially associated with the traits of interest. The results of this study may facilitate the potential use of the genes involved in growth and production traits for the genetic improvement of productivity in sheep. ABSTRACT: Body weight is an important economic trait for sheep and it is vital for their successful production and breeding. Therefore, identifying the genomic regions and biological pathways that contribute to understanding variability in body weight traits is significant for selection purposes. In this study, the genome-wide associations of birth, weaning, yearling, and adult weights of 460 fine-wool sheep were determined using resequencing technology. The results showed that 113 single nucleotide polymorphisms (SNPs) reached the genome-wide significance levels for the four body weight traits and 30 genes were annotated effectively, including AADACL3, VGF, NPC1, and SERPINA12. The genes annotated by these SNPs significantly enriched 78 gene ontology terms and 25 signaling pathways, and were found to mainly participate in skeletal muscle development and lipid metabolism. These genes can be used as candidate genes for body weight in sheep, and provide useful information for the production and genomic selection of Chinese fine-wool sheep. |
format | Online Article Text |
id | pubmed-7022301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70223012020-03-09 Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep Lu, Zengkui Yue, Yaojing Yuan, Chao Liu, Jianbin Chen, Zhiqiang Niu, Chune Sun, Xiaoping Zhu, Shaohua Zhao, Hongchang Guo, Tingting Yang, Bohui Animals (Basel) Article SIMPLE SUMMARY: Body weight traits are economically important in the sheep industry, and it is critical to explore their underlying genetic architecture. Hence, four body weight traits, including birth, weaning, yearling, and adult weights were examined. Through a genome-wide association study on Chinese fine-wool sheep, several candidate single-nucleotide polymorphisms (SNPs) and genes were found potentially associated with the traits of interest. The results of this study may facilitate the potential use of the genes involved in growth and production traits for the genetic improvement of productivity in sheep. ABSTRACT: Body weight is an important economic trait for sheep and it is vital for their successful production and breeding. Therefore, identifying the genomic regions and biological pathways that contribute to understanding variability in body weight traits is significant for selection purposes. In this study, the genome-wide associations of birth, weaning, yearling, and adult weights of 460 fine-wool sheep were determined using resequencing technology. The results showed that 113 single nucleotide polymorphisms (SNPs) reached the genome-wide significance levels for the four body weight traits and 30 genes were annotated effectively, including AADACL3, VGF, NPC1, and SERPINA12. The genes annotated by these SNPs significantly enriched 78 gene ontology terms and 25 signaling pathways, and were found to mainly participate in skeletal muscle development and lipid metabolism. These genes can be used as candidate genes for body weight in sheep, and provide useful information for the production and genomic selection of Chinese fine-wool sheep. MDPI 2020-01-19 /pmc/articles/PMC7022301/ /pubmed/31963922 http://dx.doi.org/10.3390/ani10010170 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lu, Zengkui Yue, Yaojing Yuan, Chao Liu, Jianbin Chen, Zhiqiang Niu, Chune Sun, Xiaoping Zhu, Shaohua Zhao, Hongchang Guo, Tingting Yang, Bohui Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep |
title | Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep |
title_full | Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep |
title_fullStr | Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep |
title_full_unstemmed | Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep |
title_short | Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep |
title_sort | genome-wide association study of body weight traits in chinese fine-wool sheep |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022301/ https://www.ncbi.nlm.nih.gov/pubmed/31963922 http://dx.doi.org/10.3390/ani10010170 |
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