The Interaction between Amyloid Prefibrillar Oligomers of Salmon Calcitonin and a Lipid-Raft Model: Molecular Mechanisms Leading to Membrane Damage, Ca(2+)-Influx and Neurotoxicity

To investigate the interaction between amyloid assemblies and “lipid-rafts”, we performed functional and structural experiments on salmon calcitonin (sCT) solutions rich in prefibrillar oligomers, proto- and mature-fibers interacting with liposomes made of monosialoganglioside-GM1 (4%), DPPC (48%) a...

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Detalles Bibliográficos
Autores principales: Diociaiuti, Marco, Bombelli, Cecilia, Zanetti-Polzi, Laura, Belfiore, Marcello, Fioravanti, Raoul, Macchia, Gianfranco, Giordani, Cristiano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022306/
https://www.ncbi.nlm.nih.gov/pubmed/31905804
http://dx.doi.org/10.3390/biom10010058

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