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Characterization of the Gut Microbiota of Individuals at Different T2D Stages Reveals a Complex Relationship with the Host

In this work, we studied 217 Mexican subjects divided into six groups with different stages of glucose intolerance: 76 Controls (CO), 54 prediabetes (PRE), 14 T2D no medication (T2D−No−M), 14 T2D with Metformin (T2D−M), 22 T2D with polypharmacy (T2D−P), and 37 T2D with polypharmacy and insulin (T2D−...

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Autores principales: Chávez-Carbajal, Alejandra, Pizano-Zárate, María Luisa, Hernández-Quiroz, Fernando, Ortiz-Luna, Guillermo Federico, Morales-Hernández, Rosa María, De Sales-Millán, Amapola, Hernández-Trejo, María, García-Vite, Angelina, Beltrán-Lagunes, Luis, Hoyo-Vadillo, Carlos, García-Mena, Jaime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022408/
https://www.ncbi.nlm.nih.gov/pubmed/31936722
http://dx.doi.org/10.3390/microorganisms8010094
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author Chávez-Carbajal, Alejandra
Pizano-Zárate, María Luisa
Hernández-Quiroz, Fernando
Ortiz-Luna, Guillermo Federico
Morales-Hernández, Rosa María
De Sales-Millán, Amapola
Hernández-Trejo, María
García-Vite, Angelina
Beltrán-Lagunes, Luis
Hoyo-Vadillo, Carlos
García-Mena, Jaime
author_facet Chávez-Carbajal, Alejandra
Pizano-Zárate, María Luisa
Hernández-Quiroz, Fernando
Ortiz-Luna, Guillermo Federico
Morales-Hernández, Rosa María
De Sales-Millán, Amapola
Hernández-Trejo, María
García-Vite, Angelina
Beltrán-Lagunes, Luis
Hoyo-Vadillo, Carlos
García-Mena, Jaime
author_sort Chávez-Carbajal, Alejandra
collection PubMed
description In this work, we studied 217 Mexican subjects divided into six groups with different stages of glucose intolerance: 76 Controls (CO), 54 prediabetes (PRE), 14 T2D no medication (T2D−No−M), 14 T2D with Metformin (T2D−M), 22 T2D with polypharmacy (T2D−P), and 37 T2D with polypharmacy and insulin (T2D−P+I). We aimed to determine differences in the gut microbiota diversity for each condition. At the phylum level, we found that Firmicutes and Bacteroidetes outline major changes in the gut microbiota. The gut bacterial richness and diversity of individuals in the T2D−No−M group were lesser than other groups. Interestingly, we found a significant difference in the beta diversity of the gut microbiota among all groups. Higher abundance was found for Comamonadaceae in PRE, and Sutterella spp. in T2D−No−M. In addition, we found associations of specific microbial taxa with clinical parameters. Finally, we report predicted metabolic pathways of gut microbiota linked to T2D−M and PRE conditions. Collectively, these results indicate that each group has specific predicted metabolic characteristics and gut bacteria populations for each phenotype. The results of this study could be used to define strategies to modulate gut microbiota through noninvasive treatments, such as dietary intervention, probiotics or prebiotics, and to improve glucose tolerance of individuals with prediabetes or T2D.
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spelling pubmed-70224082020-03-09 Characterization of the Gut Microbiota of Individuals at Different T2D Stages Reveals a Complex Relationship with the Host Chávez-Carbajal, Alejandra Pizano-Zárate, María Luisa Hernández-Quiroz, Fernando Ortiz-Luna, Guillermo Federico Morales-Hernández, Rosa María De Sales-Millán, Amapola Hernández-Trejo, María García-Vite, Angelina Beltrán-Lagunes, Luis Hoyo-Vadillo, Carlos García-Mena, Jaime Microorganisms Article In this work, we studied 217 Mexican subjects divided into six groups with different stages of glucose intolerance: 76 Controls (CO), 54 prediabetes (PRE), 14 T2D no medication (T2D−No−M), 14 T2D with Metformin (T2D−M), 22 T2D with polypharmacy (T2D−P), and 37 T2D with polypharmacy and insulin (T2D−P+I). We aimed to determine differences in the gut microbiota diversity for each condition. At the phylum level, we found that Firmicutes and Bacteroidetes outline major changes in the gut microbiota. The gut bacterial richness and diversity of individuals in the T2D−No−M group were lesser than other groups. Interestingly, we found a significant difference in the beta diversity of the gut microbiota among all groups. Higher abundance was found for Comamonadaceae in PRE, and Sutterella spp. in T2D−No−M. In addition, we found associations of specific microbial taxa with clinical parameters. Finally, we report predicted metabolic pathways of gut microbiota linked to T2D−M and PRE conditions. Collectively, these results indicate that each group has specific predicted metabolic characteristics and gut bacteria populations for each phenotype. The results of this study could be used to define strategies to modulate gut microbiota through noninvasive treatments, such as dietary intervention, probiotics or prebiotics, and to improve glucose tolerance of individuals with prediabetes or T2D. MDPI 2020-01-10 /pmc/articles/PMC7022408/ /pubmed/31936722 http://dx.doi.org/10.3390/microorganisms8010094 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chávez-Carbajal, Alejandra
Pizano-Zárate, María Luisa
Hernández-Quiroz, Fernando
Ortiz-Luna, Guillermo Federico
Morales-Hernández, Rosa María
De Sales-Millán, Amapola
Hernández-Trejo, María
García-Vite, Angelina
Beltrán-Lagunes, Luis
Hoyo-Vadillo, Carlos
García-Mena, Jaime
Characterization of the Gut Microbiota of Individuals at Different T2D Stages Reveals a Complex Relationship with the Host
title Characterization of the Gut Microbiota of Individuals at Different T2D Stages Reveals a Complex Relationship with the Host
title_full Characterization of the Gut Microbiota of Individuals at Different T2D Stages Reveals a Complex Relationship with the Host
title_fullStr Characterization of the Gut Microbiota of Individuals at Different T2D Stages Reveals a Complex Relationship with the Host
title_full_unstemmed Characterization of the Gut Microbiota of Individuals at Different T2D Stages Reveals a Complex Relationship with the Host
title_short Characterization of the Gut Microbiota of Individuals at Different T2D Stages Reveals a Complex Relationship with the Host
title_sort characterization of the gut microbiota of individuals at different t2d stages reveals a complex relationship with the host
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022408/
https://www.ncbi.nlm.nih.gov/pubmed/31936722
http://dx.doi.org/10.3390/microorganisms8010094
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