Cargando…

Mucoepidermoid Carcinoma of the Uterine Cervix—Single-Center Study Over a 10-Year Period

Background and objectives: Adenosquamous cancer of the uterine cervix is a rare type of cervical cancer with both malignant squamous and glandular components. A very rare subtype is mucoepidermoid carcinoma (MEC), which was first described as a salivary gland tumor. It has been described as having t...

Descripción completa

Detalles Bibliográficos
Autores principales: Yordanov, Angel, Karamanliev, Martin, Tantchev, Latchezar, Konsoulova, Assia, Strashilov, Strahil, Vasileva-Slaveva, Mariela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022544/
https://www.ncbi.nlm.nih.gov/pubmed/31963763
http://dx.doi.org/10.3390/medicina56010037
_version_ 1783498039853318144
author Yordanov, Angel
Karamanliev, Martin
Tantchev, Latchezar
Konsoulova, Assia
Strashilov, Strahil
Vasileva-Slaveva, Mariela
author_facet Yordanov, Angel
Karamanliev, Martin
Tantchev, Latchezar
Konsoulova, Assia
Strashilov, Strahil
Vasileva-Slaveva, Mariela
author_sort Yordanov, Angel
collection PubMed
description Background and objectives: Adenosquamous cancer of the uterine cervix is a rare type of cervical cancer with both malignant squamous and glandular components. A very rare subtype is mucoepidermoid carcinoma (MEC), which was first described as a salivary gland tumor. It has been described as having the appearance of a squamous cell carcinoma without glandular formation and contains intracellular mucin. The postoperative evolution of this tumor and the potentially poorer prognosis may indicate an intensification of the follow-up. The objective of our study was to analyze the frequency of mucoepidermoid carcinoma in hospitalized women with cervical cancer, clinical characteristics and prognosis. Material and Methods: A retrospective study of all cases of mucoepidermoid carcinoma of the cervix at Department of Gynecologic Oncology, University Hospital—Pleven, Pleven Bulgaria between 1 January 2007 and 31 December 2016 was performed. All patients were followed-up till December 2019. We analyzed certain clinical characteristics of the patients; calculated the frequency of mucoepidermoid carcinoma of the cervix from all patients with stage I cervical cancer; and looked at the overall survival rate, correlation between overall survival, lymph node status and the size of the tumor. Results: The frequency of MEC was 1.12% of all patients with stage I cervical cancer in this study. The median age of the patients with MEC was 46.7 years (range 38–62). Four patients (57.1%) were staged as FIGO IB1, and three patients (42.8%) were FIGO IB2. The size of the primary tumor was <2 cm in 2 patients (28.57%), 2–4 cm in 2 patients (28.57%) and >4 cm in 3 patients (42.8%). Metastatic lymph nodes were found in two patients (28.57%), and nonmetastatic lymph nodes were found in five patients (71.43%). There were two (28.57%) disease-related deaths during the study period. The five-year observed survival in the MEC group was 85.7% and in the other subtypes of adenosquamous cancer group was 78.3%. Conclusions: MEC of the uterine cervix is a rare entity diagnosis. As a mucin-producing tumor, it is frequently regarded as a subtype with worse clinical behavior and patients’ outcomes. Nevertheless, our data did not confirm this prognosis. New molecular markers and better stratification are needed for better selection of patients with CC, which may benefit more from additional treatment and new target therapies.
format Online
Article
Text
id pubmed-7022544
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-70225442020-03-09 Mucoepidermoid Carcinoma of the Uterine Cervix—Single-Center Study Over a 10-Year Period Yordanov, Angel Karamanliev, Martin Tantchev, Latchezar Konsoulova, Assia Strashilov, Strahil Vasileva-Slaveva, Mariela Medicina (Kaunas) Article Background and objectives: Adenosquamous cancer of the uterine cervix is a rare type of cervical cancer with both malignant squamous and glandular components. A very rare subtype is mucoepidermoid carcinoma (MEC), which was first described as a salivary gland tumor. It has been described as having the appearance of a squamous cell carcinoma without glandular formation and contains intracellular mucin. The postoperative evolution of this tumor and the potentially poorer prognosis may indicate an intensification of the follow-up. The objective of our study was to analyze the frequency of mucoepidermoid carcinoma in hospitalized women with cervical cancer, clinical characteristics and prognosis. Material and Methods: A retrospective study of all cases of mucoepidermoid carcinoma of the cervix at Department of Gynecologic Oncology, University Hospital—Pleven, Pleven Bulgaria between 1 January 2007 and 31 December 2016 was performed. All patients were followed-up till December 2019. We analyzed certain clinical characteristics of the patients; calculated the frequency of mucoepidermoid carcinoma of the cervix from all patients with stage I cervical cancer; and looked at the overall survival rate, correlation between overall survival, lymph node status and the size of the tumor. Results: The frequency of MEC was 1.12% of all patients with stage I cervical cancer in this study. The median age of the patients with MEC was 46.7 years (range 38–62). Four patients (57.1%) were staged as FIGO IB1, and three patients (42.8%) were FIGO IB2. The size of the primary tumor was <2 cm in 2 patients (28.57%), 2–4 cm in 2 patients (28.57%) and >4 cm in 3 patients (42.8%). Metastatic lymph nodes were found in two patients (28.57%), and nonmetastatic lymph nodes were found in five patients (71.43%). There were two (28.57%) disease-related deaths during the study period. The five-year observed survival in the MEC group was 85.7% and in the other subtypes of adenosquamous cancer group was 78.3%. Conclusions: MEC of the uterine cervix is a rare entity diagnosis. As a mucin-producing tumor, it is frequently regarded as a subtype with worse clinical behavior and patients’ outcomes. Nevertheless, our data did not confirm this prognosis. New molecular markers and better stratification are needed for better selection of patients with CC, which may benefit more from additional treatment and new target therapies. MDPI 2020-01-18 /pmc/articles/PMC7022544/ /pubmed/31963763 http://dx.doi.org/10.3390/medicina56010037 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yordanov, Angel
Karamanliev, Martin
Tantchev, Latchezar
Konsoulova, Assia
Strashilov, Strahil
Vasileva-Slaveva, Mariela
Mucoepidermoid Carcinoma of the Uterine Cervix—Single-Center Study Over a 10-Year Period
title Mucoepidermoid Carcinoma of the Uterine Cervix—Single-Center Study Over a 10-Year Period
title_full Mucoepidermoid Carcinoma of the Uterine Cervix—Single-Center Study Over a 10-Year Period
title_fullStr Mucoepidermoid Carcinoma of the Uterine Cervix—Single-Center Study Over a 10-Year Period
title_full_unstemmed Mucoepidermoid Carcinoma of the Uterine Cervix—Single-Center Study Over a 10-Year Period
title_short Mucoepidermoid Carcinoma of the Uterine Cervix—Single-Center Study Over a 10-Year Period
title_sort mucoepidermoid carcinoma of the uterine cervix—single-center study over a 10-year period
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022544/
https://www.ncbi.nlm.nih.gov/pubmed/31963763
http://dx.doi.org/10.3390/medicina56010037
work_keys_str_mv AT yordanovangel mucoepidermoidcarcinomaoftheuterinecervixsinglecenterstudyovera10yearperiod
AT karamanlievmartin mucoepidermoidcarcinomaoftheuterinecervixsinglecenterstudyovera10yearperiod
AT tantchevlatchezar mucoepidermoidcarcinomaoftheuterinecervixsinglecenterstudyovera10yearperiod
AT konsoulovaassia mucoepidermoidcarcinomaoftheuterinecervixsinglecenterstudyovera10yearperiod
AT strashilovstrahil mucoepidermoidcarcinomaoftheuterinecervixsinglecenterstudyovera10yearperiod
AT vasilevaslavevamariela mucoepidermoidcarcinomaoftheuterinecervixsinglecenterstudyovera10yearperiod