Cargando…

In Vitro and In Vivo Models for the Investigation of Potential Drugs Against Schizophrenia

Schizophrenia (SZ) is a complex psychiatric disorder characterized by positive, negative, and cognitive symptoms, and is not satisfactorily treated by current antipsychotics. Progress in understanding the basic pathomechanism of the disease has been hampered by the lack of appropriate models. In ord...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koszła, Oliwia, Targowska-Duda, Katarzyna M., Kędzierska, Ewa, Kaczor, Agnieszka A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022578/ https://www.ncbi.nlm.nih.gov/pubmed/31963851 http://dx.doi.org/10.3390/biom10010160

Ejemplares similares

Funnel metadynamics and behavioral studies reveal complex effect of D2AAK1 ligand on anxiety-like processes
por: Bartuzi, Damian, et al.
Publicado: (2022)

Current Approaches and Tools Used in Drug Development against Parkinson’s Disease
por: Koszła, Oliwia, et al.
Publicado: (2021)

Screening and Structure–Activity Relationship of D2AAK1 Derivatives for Potential Application in the Treatment of Neurodegenerative Diseases
por: Koszła, Oliwia, et al.
Publicado: (2022)

The Antipsychotic D2AAK1 as a Memory Enhancer for Treatment of Mental and Neurodegenerative Diseases
por: Koszła, Oliwia, et al.
Publicado: (2020)

Recent Advances and Applications of Molecular Docking to G Protein-Coupled Receptors
por: Bartuzi, Damian, et al.
Publicado: (2017)

N-(2-Hydroxyphenyl)-1-[3-(2-oxo-2,3-dihydro-1H- benzimidazol-1-yl)propyl]piperidine-4-Carboxamide (D2AAK4), a Multi-Target Ligand of Aminergic GPCRs, as a Potential Antipsychotic
por: Kaczor, Agnieszka A., et al.
Publicado: (2020)

Multi-Target Approach for Drug Discovery against Schizophrenia
por: Kondej, Magda, et al.
Publicado: (2018)

Novel Positive Allosteric Modulators of µ Opioid Receptor—Insight from In Silico and In Vivo Studies
por: Bartuzi, Damian, et al.
Publicado: (2020)

Allosteric modulation of dopamine D(2L) receptor in complex with G(i1) and G(i2) proteins: the effect of subtle structural and stereochemical ligand modifications
por: Żuk, Justyna, et al.
Publicado: (2022)

Comparative molecular field analysis and molecular dynamics studies of α/β hydrolase domain containing 6 (ABHD6) inhibitors
por: Kaczor, Agnieszka A., et al.
Publicado: (2015)

Novel multi-target ligands of dopamine and serotonin receptors for the treatment of schizophrenia based on indazole and piperazine scaffolds–synthesis, biological activity, and structural evaluation
por: Stępnicki, Piotr, et al.
Publicado: (2023)

In Vitro Investigation of Binding Interactions between Albumin–Gliclazide Model and Typical Hypotensive Drugs
por: Zurawska-Plaksej, Ewa, et al.
Publicado: (2021)

Influence of Cyclooxygenase-2 Inhibitors on Kynurenic Acid Production in Rat Brain in Vitro
por: Zakrocka, Izabela, et al.
Publicado: (2018)

Relationship between GABA-Ergic System and the Expression of Mephedrone-Induced Reward in Rats—Behavioral, Chromatographic and In Vivo Imaging Study
por: Wronikowska-Denysiuk, Olga, et al.
Publicado: (2023)

Development and Characterization of Novel Selective, Non-Basic Dopamine D(2) Receptor Antagonists for the Treatment of Schizophrenia
por: Stępnicki, Piotr, et al.
Publicado: (2023)

Neuronal life or death linked to depression treatment: the interplay between drugs and their stress-related outcomes relate to single or combined drug therapies
por: Solek, Przemyslaw, et al.
Publicado: (2019)

Synthesis of Novel 2-(Cyclopentylamino)thiazol-4(5H)-one Derivatives with Potential Anticancer, Antioxidant, and 11β-HSD Inhibitory Activities
por: Baumgart, Szymon, et al.
Publicado: (2023)

Current Concepts and Treatments of Schizophrenia
por: Stępnicki, Piotr, et al.
Publicado: (2018)

Synthesis, central nervous system activity, and structure–activity relationship of 1-aryl-6-benzyl-7-hydroxy-2,3-dihydroimidazo[1,2-a]pyrimidine-5(1H)-ones
por: Rządkowska, Marzena, et al.
Publicado: (2014)

Synthesis, Central Nervous System Activity and Structure-Activity Relationships of Novel 1-(1-Alkyl-4-aryl-4,5-dihydro-1H-imidazo)-3-substituted Urea Derivatives
por: Szacoń, Elżbieta, et al.
Publicado: (2015)

Carlina oxide inhibits the interaction of SARS-CoV-2 S glycoprotein with angiotensin-converting enzyme 2
por: Wnorowska, Sylwia, et al.
Publicado: (2022)

Synthesis and Pharmacological Evaluation of Novel 1-(1,4-Alkylaryldisubstituted-4,5-dihydro-1H-imidazo)-3-substituted Urea Derivatives
por: Szacoń, Elżbieta, et al.
Publicado: (2016)

Synthesis, Structural and Behavioral Studies of Indole Derivatives D2AAK5, D2AAK6 and D2AAK7 as Serotonin 5-HT(1A) and 5-HT(2A) Receptor Ligands
por: Kaczor, Agnieszka A., et al.
Publicado: (2023)

Investigating the antifibrotic effect of the antiparasitic drug Praziquantel in in vitro and in vivo preclinical models
por: Nono, Justin Komguep, et al.
Publicado: (2020)

Molecular Interactions between Mecamylamine Enantiomers and the Transmembrane Domain of the Human α4β2 Nicotinic Receptor
por: Bondarenko, Vasyl, et al.
Publicado: (2014)

Is the Antidepressant Activity of Selective Serotonin Reuptake Inhibitors Mediated by Nicotinic Acetylcholine Receptors?
por: Arias, Hugo R., et al.
Publicado: (2021)

Assessment of FDA-approved drugs against Strongyloides ratti in vitro and in vivo to identify potentially active drugs against strongyloidiasis
por: Keiser, Jennifer, et al.
Publicado: (2021)

Comparison of thyroid-stimulating hormone levels in adolescents with schizophrenia, bipolar disorder, unipolar depression, conduct disorders, and hyperkinetic disorders
por: Makarow-Gronert, Agnieszka, et al.
Publicado: (2021)

Efficacy of Dabrafenib and Trametinib in a Patient with Squamous-Cell Carcinoma, with Mutation p.D594G in BRAF and p.R461* in NF1 Genes—A Case Report with Literature Review
por: Grenda, Anna, et al.
Publicado: (2023)

Angiotensin II Type 1 Receptor Blockers Inhibit KAT II Activity in the Brain—Its Possible Clinical Applications
por: Zakrocka, Izabela, et al.
Publicado: (2017)

Zirconium-Based Metal–Organic Frameworks as Acriflavine Cargos in the Battle against Coronaviruses—A Theoretical and Experimental Approach
por: Jodłowski, Przemysław J., et al.
Publicado: (2022)

2,4-Dichlorophenoxyacetic Thiosemicarbazides as a New Class of Compounds against Stomach Cancer Potentially Intercalating with DNA †
por: Pitucha, Monika, et al.
Publicado: (2020)

Defensive Impact of Kaempferide Against Neurodegenerative Studies: In Vitro and In Vivo Investigations
por: Nalla, Swathi, et al.
Publicado: (2023)

In-Vitro and Ex-Vivo Investigations of the Microtubule Binding Drug Targetin on Angiogenesis
por: Ajeawung, Norbert F., et al.
Publicado: (2013)

Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations
por: Bocheńska, Katarzyna, et al.
Publicado: (2021)

Repurposing Disulfiram (Tetraethylthiuram Disulfide) as a Potential Drug Candidate against Borrelia burgdorferi In Vitro and In Vivo
por: Potula, Hari-Hara S. K., et al.
Publicado: (2020)

In Vitro, In Vivo, and In Silico Studies of Cumanin Diacetate as a Potential Drug against Trypanosoma cruzi Infection
por: Sánchez Alberti, Andrés, et al.
Publicado: (2021)

6-Gingerol, a Major Constituent of Zingiber officinale Rhizoma, Exerts Anticonvulsant Activity in the Pentylenetetrazole-Induced Seizure Model in Larval Zebrafish
por: Gawel, Kinga, et al.
Publicado: (2021)

Repurposing of anticancer drugs: in vitro and in vivo activities against Schistosoma mansoni
por: Cowan, Noemi, et al.
Publicado: (2015)

Integrating In Vitro, Modeling, and In Vivo Approaches to Investigate Warfarin Bioequivalence
por: Zhang, X, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_86a24hi7uk08l1vb0mrpopjb13