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Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements
Colon targeted drug delivery systems have gained a great deal of attention as potential carriers for the local treatment of colonic diseases with reduced systemic side effects and also for the enhanced oral delivery of various therapeutics vulnerable to acidic and enzymatic degradation in the upper...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022598/ https://www.ncbi.nlm.nih.gov/pubmed/31952340 http://dx.doi.org/10.3390/pharmaceutics12010068 |
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author | Lee, Sang Hoon Bajracharya, Rajiv Min, Jeong Youn Han, Ji-Won Park, Byeong Ju Han, Hyo-Kyung |
author_facet | Lee, Sang Hoon Bajracharya, Rajiv Min, Jeong Youn Han, Ji-Won Park, Byeong Ju Han, Hyo-Kyung |
author_sort | Lee, Sang Hoon |
collection | PubMed |
description | Colon targeted drug delivery systems have gained a great deal of attention as potential carriers for the local treatment of colonic diseases with reduced systemic side effects and also for the enhanced oral delivery of various therapeutics vulnerable to acidic and enzymatic degradation in the upper gastrointestinal tract. In recent years, the global pharmaceutical market for biologics has grown, and increasing demand for a more patient-friendly drug administration system highlights the importance of colonic drug delivery as a noninvasive delivery approach for macromolecules. Colon-targeted drug delivery systems for macromolecules can provide therapeutic benefits including better patient compliance (because they are pain-free and can be self-administered) and lower costs. Therefore, to achieve more efficient colonic drug delivery for local or systemic drug effects, various strategies have been explored including pH-dependent systems, enzyme-triggered systems, receptor-mediated systems, and magnetically-driven systems. In this review, recent advancements in various approaches for designing colon targeted drug delivery systems and their pharmaceutical applications are covered with a particular emphasis on formulation technologies. |
format | Online Article Text |
id | pubmed-7022598 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70225982020-03-09 Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements Lee, Sang Hoon Bajracharya, Rajiv Min, Jeong Youn Han, Ji-Won Park, Byeong Ju Han, Hyo-Kyung Pharmaceutics Review Colon targeted drug delivery systems have gained a great deal of attention as potential carriers for the local treatment of colonic diseases with reduced systemic side effects and also for the enhanced oral delivery of various therapeutics vulnerable to acidic and enzymatic degradation in the upper gastrointestinal tract. In recent years, the global pharmaceutical market for biologics has grown, and increasing demand for a more patient-friendly drug administration system highlights the importance of colonic drug delivery as a noninvasive delivery approach for macromolecules. Colon-targeted drug delivery systems for macromolecules can provide therapeutic benefits including better patient compliance (because they are pain-free and can be self-administered) and lower costs. Therefore, to achieve more efficient colonic drug delivery for local or systemic drug effects, various strategies have been explored including pH-dependent systems, enzyme-triggered systems, receptor-mediated systems, and magnetically-driven systems. In this review, recent advancements in various approaches for designing colon targeted drug delivery systems and their pharmaceutical applications are covered with a particular emphasis on formulation technologies. MDPI 2020-01-15 /pmc/articles/PMC7022598/ /pubmed/31952340 http://dx.doi.org/10.3390/pharmaceutics12010068 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lee, Sang Hoon Bajracharya, Rajiv Min, Jeong Youn Han, Ji-Won Park, Byeong Ju Han, Hyo-Kyung Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements |
title | Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements |
title_full | Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements |
title_fullStr | Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements |
title_full_unstemmed | Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements |
title_short | Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements |
title_sort | strategic approaches for colon targeted drug delivery: an overview of recent advancements |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022598/ https://www.ncbi.nlm.nih.gov/pubmed/31952340 http://dx.doi.org/10.3390/pharmaceutics12010068 |
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