Lysosomal Fusion: An Efficient Mechanism Increasing Their Sequestration Capacity for Weak Base Drugs without Apparent Lysosomal Biogenesis

Lysosomal sequestration of anticancer therapeutics lowers their cytotoxic potential, reduces drug availability at target sites, and contributes to cancer resistance. Only recently has it been shown that lysosomal sequestration of weak base drugs induces lysosomal biogenesis mediated by activation of...

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Detalles Bibliográficos
Autores principales: Skoupa, Nikola, Dolezel, Petr, Mlejnek, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022710/
https://www.ncbi.nlm.nih.gov/pubmed/31947839
http://dx.doi.org/10.3390/biom10010077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022710/
https://www.ncbi.nlm.nih.gov/pubmed/31947839
http://dx.doi.org/10.3390/biom10010077

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