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Effects of Allium mongolicum Regel and Its Flavonoids on Constipation
Constipation is a common bowel disease in adults with the symptoms of dry stool or difficulty passing stool. Compared with medication therapy, patients show more compliance with the diet therapy, and thus the diet therapy normally exhibits better therapeutic effect. Allium mongolicum Regel s a peren...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022811/ https://www.ncbi.nlm.nih.gov/pubmed/31877639 http://dx.doi.org/10.3390/biom10010014 |
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author | Chen, Yue Ding, Zhijuan Wu, Yuzheng Chen, Qian Liu, Mengyang Yu, Haiyang Wang, Dan Zhang, Yi Wang, Tao |
author_facet | Chen, Yue Ding, Zhijuan Wu, Yuzheng Chen, Qian Liu, Mengyang Yu, Haiyang Wang, Dan Zhang, Yi Wang, Tao |
author_sort | Chen, Yue |
collection | PubMed |
description | Constipation is a common bowel disease in adults with the symptoms of dry stool or difficulty passing stool. Compared with medication therapy, patients show more compliance with the diet therapy, and thus the diet therapy normally exhibits better therapeutic effect. Allium mongolicum Regel s a perennial herb of Liliaceae native to Mongolia, Kazakhstan, and China, which is traditionally used for constipation. In this paper, we partly clarify the effectiveness of A. mongolicum on constipation from two aspects, including maintaining colon water content and increasing intestinal transit. In loperamide-induced constipation mice model, nine days oral administration of A. mongolicum 50% ethanolic extract increased luminal side water content and regulated intestinal movement rhythm to normalize stools. The activity at least partly related to down-regulation of colon aquaporins 3 (AQP3) expression, and up-regulation and activation of G protein alpha (Gα) and phosphoinositide 3-kinases (PI3K). Further, activities on intestine movements were tested using compounds isolated from A. mongolicum. Three kinds of major flavonoids significantly increased cellular calcium flux in HCT116 cells and promoted mice intestine smooth muscle contraction. The activity may be related to M choline receptor, μ opioid receptor, 5-HT3 receptor, and inositol 1,4,5-trisphosphate (IP3) receptor. |
format | Online Article Text |
id | pubmed-7022811 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70228112020-03-11 Effects of Allium mongolicum Regel and Its Flavonoids on Constipation Chen, Yue Ding, Zhijuan Wu, Yuzheng Chen, Qian Liu, Mengyang Yu, Haiyang Wang, Dan Zhang, Yi Wang, Tao Biomolecules Article Constipation is a common bowel disease in adults with the symptoms of dry stool or difficulty passing stool. Compared with medication therapy, patients show more compliance with the diet therapy, and thus the diet therapy normally exhibits better therapeutic effect. Allium mongolicum Regel s a perennial herb of Liliaceae native to Mongolia, Kazakhstan, and China, which is traditionally used for constipation. In this paper, we partly clarify the effectiveness of A. mongolicum on constipation from two aspects, including maintaining colon water content and increasing intestinal transit. In loperamide-induced constipation mice model, nine days oral administration of A. mongolicum 50% ethanolic extract increased luminal side water content and regulated intestinal movement rhythm to normalize stools. The activity at least partly related to down-regulation of colon aquaporins 3 (AQP3) expression, and up-regulation and activation of G protein alpha (Gα) and phosphoinositide 3-kinases (PI3K). Further, activities on intestine movements were tested using compounds isolated from A. mongolicum. Three kinds of major flavonoids significantly increased cellular calcium flux in HCT116 cells and promoted mice intestine smooth muscle contraction. The activity may be related to M choline receptor, μ opioid receptor, 5-HT3 receptor, and inositol 1,4,5-trisphosphate (IP3) receptor. MDPI 2019-12-20 /pmc/articles/PMC7022811/ /pubmed/31877639 http://dx.doi.org/10.3390/biom10010014 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chen, Yue Ding, Zhijuan Wu, Yuzheng Chen, Qian Liu, Mengyang Yu, Haiyang Wang, Dan Zhang, Yi Wang, Tao Effects of Allium mongolicum Regel and Its Flavonoids on Constipation |
title | Effects of Allium mongolicum Regel and Its Flavonoids on Constipation |
title_full | Effects of Allium mongolicum Regel and Its Flavonoids on Constipation |
title_fullStr | Effects of Allium mongolicum Regel and Its Flavonoids on Constipation |
title_full_unstemmed | Effects of Allium mongolicum Regel and Its Flavonoids on Constipation |
title_short | Effects of Allium mongolicum Regel and Its Flavonoids on Constipation |
title_sort | effects of allium mongolicum regel and its flavonoids on constipation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022811/ https://www.ncbi.nlm.nih.gov/pubmed/31877639 http://dx.doi.org/10.3390/biom10010014 |
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