Cargando…

Polyethylene Glycol-Chitosan Oligosaccharide-Coated Superparamagnetic Iron Oxide Nanoparticles: A Novel Drug Delivery System for Curcumin Diglutaric Acid

Curcumin diglutaric acid-loaded polyethylene glycol-chitosan oligosaccharide-coated superparamagnetic iron oxide nanoparticles (CG-PEG-CSO-SPIONs) were fabricated by co-precipitation and optimized using a Box–Behnken statistical design in order to achieve the minimum size, optimal zeta potential (≥...

Descripción completa

Detalles Bibliográficos
Autores principales: Sorasitthiyanukarn, Feuangthit Niyamissara, Muangnoi, Chawanphat, Thaweesest, Wuttinont, Ratnatilaka Na Bhuket, Pahweenvaj, Jantaratana, Pongsakorn, Rojsitthisak, Pornchai, Rojsitthisak, Pranee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023009/
https://www.ncbi.nlm.nih.gov/pubmed/31906490
http://dx.doi.org/10.3390/biom10010073
_version_ 1783498149685362688
author Sorasitthiyanukarn, Feuangthit Niyamissara
Muangnoi, Chawanphat
Thaweesest, Wuttinont
Ratnatilaka Na Bhuket, Pahweenvaj
Jantaratana, Pongsakorn
Rojsitthisak, Pornchai
Rojsitthisak, Pranee
author_facet Sorasitthiyanukarn, Feuangthit Niyamissara
Muangnoi, Chawanphat
Thaweesest, Wuttinont
Ratnatilaka Na Bhuket, Pahweenvaj
Jantaratana, Pongsakorn
Rojsitthisak, Pornchai
Rojsitthisak, Pranee
author_sort Sorasitthiyanukarn, Feuangthit Niyamissara
collection PubMed
description Curcumin diglutaric acid-loaded polyethylene glycol-chitosan oligosaccharide-coated superparamagnetic iron oxide nanoparticles (CG-PEG-CSO-SPIONs) were fabricated by co-precipitation and optimized using a Box–Behnken statistical design in order to achieve the minimum size, optimal zeta potential (≥ ±20 mV), and maximum loading efficiency and capacity. The results demonstrated that CG-PEG-CSO-SPIONs prepared under the optimal condition were almost spherical in shape with a smooth surface, a diameter of 130 nm, zeta potential of 30.6 mV, loading efficiency of 83.3%, and loading capacity of 8.3%. The vibrating sample magnetometer results of the optimized CG-PEG-CSO-SPIONs showed a superparamagnetic behavior. Fourier transform infrared spectroscopy and X-ray diffraction analyses indicated that the CG physically interacted with PEG-CSO-SPIONs. In addition, the CG-PEG-CSO-SPIONs could be stored dry for up to 12 weeks or in aqueous solution for up to 4 days at either 4 °C or 25 °C with no loss of stability. The CG-PEG-CSO-SPIONs exhibited a sustained release profile up to 72 h under simulated physiological (pH 7.4) and tumor extracellular (pH 5.5) environments. Furthermore, the CG-PEG-CSO-SPIONs showed little non-specific protein binding in the simulated physiological environment. The CG-PEG-CSO-SPIONs enhanced the cellular uptake and cytotoxicity of CG against human colorectal adenocarcinoma HT-29 cells compared to free CG, and more CG was delivered to the cells after applying an external magnetic field. The overall results suggest that PEG-CSO-SPIONs have potential to be used as a novel drug delivery system for CG.
format Online
Article
Text
id pubmed-7023009
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-70230092020-03-12 Polyethylene Glycol-Chitosan Oligosaccharide-Coated Superparamagnetic Iron Oxide Nanoparticles: A Novel Drug Delivery System for Curcumin Diglutaric Acid Sorasitthiyanukarn, Feuangthit Niyamissara Muangnoi, Chawanphat Thaweesest, Wuttinont Ratnatilaka Na Bhuket, Pahweenvaj Jantaratana, Pongsakorn Rojsitthisak, Pornchai Rojsitthisak, Pranee Biomolecules Article Curcumin diglutaric acid-loaded polyethylene glycol-chitosan oligosaccharide-coated superparamagnetic iron oxide nanoparticles (CG-PEG-CSO-SPIONs) were fabricated by co-precipitation and optimized using a Box–Behnken statistical design in order to achieve the minimum size, optimal zeta potential (≥ ±20 mV), and maximum loading efficiency and capacity. The results demonstrated that CG-PEG-CSO-SPIONs prepared under the optimal condition were almost spherical in shape with a smooth surface, a diameter of 130 nm, zeta potential of 30.6 mV, loading efficiency of 83.3%, and loading capacity of 8.3%. The vibrating sample magnetometer results of the optimized CG-PEG-CSO-SPIONs showed a superparamagnetic behavior. Fourier transform infrared spectroscopy and X-ray diffraction analyses indicated that the CG physically interacted with PEG-CSO-SPIONs. In addition, the CG-PEG-CSO-SPIONs could be stored dry for up to 12 weeks or in aqueous solution for up to 4 days at either 4 °C or 25 °C with no loss of stability. The CG-PEG-CSO-SPIONs exhibited a sustained release profile up to 72 h under simulated physiological (pH 7.4) and tumor extracellular (pH 5.5) environments. Furthermore, the CG-PEG-CSO-SPIONs showed little non-specific protein binding in the simulated physiological environment. The CG-PEG-CSO-SPIONs enhanced the cellular uptake and cytotoxicity of CG against human colorectal adenocarcinoma HT-29 cells compared to free CG, and more CG was delivered to the cells after applying an external magnetic field. The overall results suggest that PEG-CSO-SPIONs have potential to be used as a novel drug delivery system for CG. MDPI 2020-01-02 /pmc/articles/PMC7023009/ /pubmed/31906490 http://dx.doi.org/10.3390/biom10010073 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sorasitthiyanukarn, Feuangthit Niyamissara
Muangnoi, Chawanphat
Thaweesest, Wuttinont
Ratnatilaka Na Bhuket, Pahweenvaj
Jantaratana, Pongsakorn
Rojsitthisak, Pornchai
Rojsitthisak, Pranee
Polyethylene Glycol-Chitosan Oligosaccharide-Coated Superparamagnetic Iron Oxide Nanoparticles: A Novel Drug Delivery System for Curcumin Diglutaric Acid
title Polyethylene Glycol-Chitosan Oligosaccharide-Coated Superparamagnetic Iron Oxide Nanoparticles: A Novel Drug Delivery System for Curcumin Diglutaric Acid
title_full Polyethylene Glycol-Chitosan Oligosaccharide-Coated Superparamagnetic Iron Oxide Nanoparticles: A Novel Drug Delivery System for Curcumin Diglutaric Acid
title_fullStr Polyethylene Glycol-Chitosan Oligosaccharide-Coated Superparamagnetic Iron Oxide Nanoparticles: A Novel Drug Delivery System for Curcumin Diglutaric Acid
title_full_unstemmed Polyethylene Glycol-Chitosan Oligosaccharide-Coated Superparamagnetic Iron Oxide Nanoparticles: A Novel Drug Delivery System for Curcumin Diglutaric Acid
title_short Polyethylene Glycol-Chitosan Oligosaccharide-Coated Superparamagnetic Iron Oxide Nanoparticles: A Novel Drug Delivery System for Curcumin Diglutaric Acid
title_sort polyethylene glycol-chitosan oligosaccharide-coated superparamagnetic iron oxide nanoparticles: a novel drug delivery system for curcumin diglutaric acid
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023009/
https://www.ncbi.nlm.nih.gov/pubmed/31906490
http://dx.doi.org/10.3390/biom10010073
work_keys_str_mv AT sorasitthiyanukarnfeuangthitniyamissara polyethyleneglycolchitosanoligosaccharidecoatedsuperparamagneticironoxidenanoparticlesanoveldrugdeliverysystemforcurcumindiglutaricacid
AT muangnoichawanphat polyethyleneglycolchitosanoligosaccharidecoatedsuperparamagneticironoxidenanoparticlesanoveldrugdeliverysystemforcurcumindiglutaricacid
AT thaweesestwuttinont polyethyleneglycolchitosanoligosaccharidecoatedsuperparamagneticironoxidenanoparticlesanoveldrugdeliverysystemforcurcumindiglutaricacid
AT ratnatilakanabhuketpahweenvaj polyethyleneglycolchitosanoligosaccharidecoatedsuperparamagneticironoxidenanoparticlesanoveldrugdeliverysystemforcurcumindiglutaricacid
AT jantaratanapongsakorn polyethyleneglycolchitosanoligosaccharidecoatedsuperparamagneticironoxidenanoparticlesanoveldrugdeliverysystemforcurcumindiglutaricacid
AT rojsitthisakpornchai polyethyleneglycolchitosanoligosaccharidecoatedsuperparamagneticironoxidenanoparticlesanoveldrugdeliverysystemforcurcumindiglutaricacid
AT rojsitthisakpranee polyethyleneglycolchitosanoligosaccharidecoatedsuperparamagneticironoxidenanoparticlesanoveldrugdeliverysystemforcurcumindiglutaricacid