PYHIN Proteins and HPV: Role in the Pathogenesis of Head and Neck Squamous Cell Carcinoma

In the last decades, the human papillomavirus (HPV) emerged as an etiological cause of head and neck squamous cell carcinoma (HNSCC), especially in the oropharynx. The role of two intracellular DNA sensors, which belong to the PYHIN family (interferon-inducible protein 16 (IFI16) and absent in melan...

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Autores principales: Riva, Giuseppe, Biolatti, Matteo, Pecorari, Giancarlo, Dell’Oste, Valentina, Landolfo, Santo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023031/
https://www.ncbi.nlm.nih.gov/pubmed/31861809
http://dx.doi.org/10.3390/microorganisms8010014
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author Riva, Giuseppe
Biolatti, Matteo
Pecorari, Giancarlo
Dell’Oste, Valentina
Landolfo, Santo
author_facet Riva, Giuseppe
Biolatti, Matteo
Pecorari, Giancarlo
Dell’Oste, Valentina
Landolfo, Santo
author_sort Riva, Giuseppe
collection PubMed
description In the last decades, the human papillomavirus (HPV) emerged as an etiological cause of head and neck squamous cell carcinoma (HNSCC), especially in the oropharynx. The role of two intracellular DNA sensors, which belong to the PYHIN family (interferon-inducible protein 16 (IFI16) and absent in melanoma 2 protein (AIM2)), has been analyzed in relation to HPV infection and head and neck carcinogenesis. In particular, IFI16 and AIM2 expression depends on HPV infection in HNSCC. They represent viral restriction factors and are key components of the intrinsic immunity activated against different viruses, including HPV. This review analyzed and summarized the recent findings about the role of PYHIN proteins in HPV(+) and HPV(−) HNSCC.
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spelling pubmed-70230312020-03-12 PYHIN Proteins and HPV: Role in the Pathogenesis of Head and Neck Squamous Cell Carcinoma Riva, Giuseppe Biolatti, Matteo Pecorari, Giancarlo Dell’Oste, Valentina Landolfo, Santo Microorganisms Review In the last decades, the human papillomavirus (HPV) emerged as an etiological cause of head and neck squamous cell carcinoma (HNSCC), especially in the oropharynx. The role of two intracellular DNA sensors, which belong to the PYHIN family (interferon-inducible protein 16 (IFI16) and absent in melanoma 2 protein (AIM2)), has been analyzed in relation to HPV infection and head and neck carcinogenesis. In particular, IFI16 and AIM2 expression depends on HPV infection in HNSCC. They represent viral restriction factors and are key components of the intrinsic immunity activated against different viruses, including HPV. This review analyzed and summarized the recent findings about the role of PYHIN proteins in HPV(+) and HPV(−) HNSCC. MDPI 2019-12-20 /pmc/articles/PMC7023031/ /pubmed/31861809 http://dx.doi.org/10.3390/microorganisms8010014 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Riva, Giuseppe
Biolatti, Matteo
Pecorari, Giancarlo
Dell’Oste, Valentina
Landolfo, Santo
PYHIN Proteins and HPV: Role in the Pathogenesis of Head and Neck Squamous Cell Carcinoma
title PYHIN Proteins and HPV: Role in the Pathogenesis of Head and Neck Squamous Cell Carcinoma
title_full PYHIN Proteins and HPV: Role in the Pathogenesis of Head and Neck Squamous Cell Carcinoma
title_fullStr PYHIN Proteins and HPV: Role in the Pathogenesis of Head and Neck Squamous Cell Carcinoma
title_full_unstemmed PYHIN Proteins and HPV: Role in the Pathogenesis of Head and Neck Squamous Cell Carcinoma
title_short PYHIN Proteins and HPV: Role in the Pathogenesis of Head and Neck Squamous Cell Carcinoma
title_sort pyhin proteins and hpv: role in the pathogenesis of head and neck squamous cell carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023031/
https://www.ncbi.nlm.nih.gov/pubmed/31861809
http://dx.doi.org/10.3390/microorganisms8010014
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