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Zein Beta-Cyclodextrin Micropowders for Iron Bisglycinate Delivery

Given the limited number of materials available to design delivery platforms for nutrients, the rational combination of raw materials already approved as food ingredients and their processing through nano-micro technology can offer a unique tool for innovation. Here, we propose a nano-in-micro strat...

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Autores principales: Esposito, Diletta, Dal Poggetto, Giovanni, Demont, Aurélie, Kraut, Nicolai, Miro, Agnese, Ungaro, Francesca, Laurienzo, Paola, Quaglia, Fabiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023128/
https://www.ncbi.nlm.nih.gov/pubmed/31940787
http://dx.doi.org/10.3390/pharmaceutics12010060
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author Esposito, Diletta
Dal Poggetto, Giovanni
Demont, Aurélie
Kraut, Nicolai
Miro, Agnese
Ungaro, Francesca
Laurienzo, Paola
Quaglia, Fabiana
author_facet Esposito, Diletta
Dal Poggetto, Giovanni
Demont, Aurélie
Kraut, Nicolai
Miro, Agnese
Ungaro, Francesca
Laurienzo, Paola
Quaglia, Fabiana
author_sort Esposito, Diletta
collection PubMed
description Given the limited number of materials available to design delivery platforms for nutrients, the rational combination of raw materials already approved as food ingredients and their processing through nano-micro technology can offer a unique tool for innovation. Here, we propose a nano-in-micro strategy to produce powders based on the hydrophobic protein zein, useful for the oral delivery of a hydrophilic iron source (iron bisglycinate) in anaemic patients. Iron-loaded powders were prepared through a two-step strategy consisting in the formation of a zein pseudolatex followed by a spray-drying step. To extend the manipulation space for zein and entrap iron bisglycinate, β-cyclodextrin (βCD) was selected as helping excipient. Addition of βCD allowed iron loading in the pseudolatex and greatly increased product yields after the drying process as compared to zein alone. Iron-loaded micro-sized powders were characterised by attenuated total reflectance–Fourier transform infrared (ATR-FTIR) spectra, thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) to elucidate the role of βCD as a compatibilizer for the zein–iron system. Remarkably, micropowders released only 20% of FeBIS in a simulated gastric fluid, whereas release in a simulated intestinal fluid was almost completed in 7 h. In summary, βCD association to zein is a novel strategy to expand applications in the oral delivery of iron bisglycinate and, prospectively, to micronutrient chelates.
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spelling pubmed-70231282020-03-12 Zein Beta-Cyclodextrin Micropowders for Iron Bisglycinate Delivery Esposito, Diletta Dal Poggetto, Giovanni Demont, Aurélie Kraut, Nicolai Miro, Agnese Ungaro, Francesca Laurienzo, Paola Quaglia, Fabiana Pharmaceutics Article Given the limited number of materials available to design delivery platforms for nutrients, the rational combination of raw materials already approved as food ingredients and their processing through nano-micro technology can offer a unique tool for innovation. Here, we propose a nano-in-micro strategy to produce powders based on the hydrophobic protein zein, useful for the oral delivery of a hydrophilic iron source (iron bisglycinate) in anaemic patients. Iron-loaded powders were prepared through a two-step strategy consisting in the formation of a zein pseudolatex followed by a spray-drying step. To extend the manipulation space for zein and entrap iron bisglycinate, β-cyclodextrin (βCD) was selected as helping excipient. Addition of βCD allowed iron loading in the pseudolatex and greatly increased product yields after the drying process as compared to zein alone. Iron-loaded micro-sized powders were characterised by attenuated total reflectance–Fourier transform infrared (ATR-FTIR) spectra, thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) to elucidate the role of βCD as a compatibilizer for the zein–iron system. Remarkably, micropowders released only 20% of FeBIS in a simulated gastric fluid, whereas release in a simulated intestinal fluid was almost completed in 7 h. In summary, βCD association to zein is a novel strategy to expand applications in the oral delivery of iron bisglycinate and, prospectively, to micronutrient chelates. MDPI 2020-01-11 /pmc/articles/PMC7023128/ /pubmed/31940787 http://dx.doi.org/10.3390/pharmaceutics12010060 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Esposito, Diletta
Dal Poggetto, Giovanni
Demont, Aurélie
Kraut, Nicolai
Miro, Agnese
Ungaro, Francesca
Laurienzo, Paola
Quaglia, Fabiana
Zein Beta-Cyclodextrin Micropowders for Iron Bisglycinate Delivery
title Zein Beta-Cyclodextrin Micropowders for Iron Bisglycinate Delivery
title_full Zein Beta-Cyclodextrin Micropowders for Iron Bisglycinate Delivery
title_fullStr Zein Beta-Cyclodextrin Micropowders for Iron Bisglycinate Delivery
title_full_unstemmed Zein Beta-Cyclodextrin Micropowders for Iron Bisglycinate Delivery
title_short Zein Beta-Cyclodextrin Micropowders for Iron Bisglycinate Delivery
title_sort zein beta-cyclodextrin micropowders for iron bisglycinate delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023128/
https://www.ncbi.nlm.nih.gov/pubmed/31940787
http://dx.doi.org/10.3390/pharmaceutics12010060
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