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Perinatal Exposure to Tartrazine Triggers Oxidative Stress and Neurobehavioral Alterations in Mice Offspring

The use of synthetic azo dyes as coloring agents in food products has dramatically increased. This study evaluated the effect of perinatal exposure to tartrazine (TZ) on mice offspring, focusing on neurobehavioral alterations and oxidative stress. The female mice received TZ (2.5 and 5 mg/kg) via or...

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Autores principales: Albasher, Gadah, Maashi, Najla, Alfarraj, Saleh, Almeer, Rafa, Albrahim, Tarfa, Alotibi, Fatimah, Bin-Jumah, May, Mahmoud, Ayman M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023231/
https://www.ncbi.nlm.nih.gov/pubmed/31936188
http://dx.doi.org/10.3390/antiox9010053
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author Albasher, Gadah
Maashi, Najla
Alfarraj, Saleh
Almeer, Rafa
Albrahim, Tarfa
Alotibi, Fatimah
Bin-Jumah, May
Mahmoud, Ayman M.
author_facet Albasher, Gadah
Maashi, Najla
Alfarraj, Saleh
Almeer, Rafa
Albrahim, Tarfa
Alotibi, Fatimah
Bin-Jumah, May
Mahmoud, Ayman M.
author_sort Albasher, Gadah
collection PubMed
description The use of synthetic azo dyes as coloring agents in food products has dramatically increased. This study evaluated the effect of perinatal exposure to tartrazine (TZ) on mice offspring, focusing on neurobehavioral alterations and oxidative stress. The female mice received TZ (2.5 and 5 mg/kg) via oral gavage during pregnancy and the first 15 days after birth. At days 21 and 35 after birth, male mice were sacrificed, and samples were collected for analyses. Perinatal exposure to TZ triggered tissue injury evidenced by the histological alterations and neuronal damage in the cerebrum, medulla oblongata, and cerebellum. TZ provoked lipid peroxidation and diminished cellular antioxidants in different brain regions of the newborns. In addition, TZ increased hemoglobin content, as well as erythrocytes, leukocytes, and platelets count at days 21 and 35 after birth. Both the locomotor behavior and anxiety reflex were significantly altered in mice exposed to TZ. In conclusion, perinatal exposure to TZ within an adequate daily intake range induced oxidative stress and neurobehavioral and hematological alterations in mice offspring. Therefore, consuming foods containing TZ during pregnancy and lactation warrants public awareness.
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spelling pubmed-70232312020-03-12 Perinatal Exposure to Tartrazine Triggers Oxidative Stress and Neurobehavioral Alterations in Mice Offspring Albasher, Gadah Maashi, Najla Alfarraj, Saleh Almeer, Rafa Albrahim, Tarfa Alotibi, Fatimah Bin-Jumah, May Mahmoud, Ayman M. Antioxidants (Basel) Article The use of synthetic azo dyes as coloring agents in food products has dramatically increased. This study evaluated the effect of perinatal exposure to tartrazine (TZ) on mice offspring, focusing on neurobehavioral alterations and oxidative stress. The female mice received TZ (2.5 and 5 mg/kg) via oral gavage during pregnancy and the first 15 days after birth. At days 21 and 35 after birth, male mice were sacrificed, and samples were collected for analyses. Perinatal exposure to TZ triggered tissue injury evidenced by the histological alterations and neuronal damage in the cerebrum, medulla oblongata, and cerebellum. TZ provoked lipid peroxidation and diminished cellular antioxidants in different brain regions of the newborns. In addition, TZ increased hemoglobin content, as well as erythrocytes, leukocytes, and platelets count at days 21 and 35 after birth. Both the locomotor behavior and anxiety reflex were significantly altered in mice exposed to TZ. In conclusion, perinatal exposure to TZ within an adequate daily intake range induced oxidative stress and neurobehavioral and hematological alterations in mice offspring. Therefore, consuming foods containing TZ during pregnancy and lactation warrants public awareness. MDPI 2020-01-08 /pmc/articles/PMC7023231/ /pubmed/31936188 http://dx.doi.org/10.3390/antiox9010053 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Albasher, Gadah
Maashi, Najla
Alfarraj, Saleh
Almeer, Rafa
Albrahim, Tarfa
Alotibi, Fatimah
Bin-Jumah, May
Mahmoud, Ayman M.
Perinatal Exposure to Tartrazine Triggers Oxidative Stress and Neurobehavioral Alterations in Mice Offspring
title Perinatal Exposure to Tartrazine Triggers Oxidative Stress and Neurobehavioral Alterations in Mice Offspring
title_full Perinatal Exposure to Tartrazine Triggers Oxidative Stress and Neurobehavioral Alterations in Mice Offspring
title_fullStr Perinatal Exposure to Tartrazine Triggers Oxidative Stress and Neurobehavioral Alterations in Mice Offspring
title_full_unstemmed Perinatal Exposure to Tartrazine Triggers Oxidative Stress and Neurobehavioral Alterations in Mice Offspring
title_short Perinatal Exposure to Tartrazine Triggers Oxidative Stress and Neurobehavioral Alterations in Mice Offspring
title_sort perinatal exposure to tartrazine triggers oxidative stress and neurobehavioral alterations in mice offspring
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023231/
https://www.ncbi.nlm.nih.gov/pubmed/31936188
http://dx.doi.org/10.3390/antiox9010053
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