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Growth Control of Adherent-Invasive Escherichia coli (AIEC) by the Predator Bacteria Bdellovibrio bacteriovorus: A New Therapeutic Approach for Crohn’s Disease Patients

In Crohn’s disease (CD) patients, intestinal dysbiosis with an overgrowth of Proteobacteria, mainly Escherichia coli, has been reported. A new pathotype of E. coli, the adherent-invasive Escherichia coli strain (AIEC), has been isolated from the mucosae of CD patients. AIEC strains play an important...

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Autores principales: Bonfiglio, Giulia, Neroni, Bruna, Radocchia, Giulia, Pompilio, Arianna, Mura, Francesco, Trancassini, Maria, Di Bonaventura, Giovanni, Pantanella, Fabrizio, Schippa, Serena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023281/
https://www.ncbi.nlm.nih.gov/pubmed/31861852
http://dx.doi.org/10.3390/microorganisms8010017
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author Bonfiglio, Giulia
Neroni, Bruna
Radocchia, Giulia
Pompilio, Arianna
Mura, Francesco
Trancassini, Maria
Di Bonaventura, Giovanni
Pantanella, Fabrizio
Schippa, Serena
author_facet Bonfiglio, Giulia
Neroni, Bruna
Radocchia, Giulia
Pompilio, Arianna
Mura, Francesco
Trancassini, Maria
Di Bonaventura, Giovanni
Pantanella, Fabrizio
Schippa, Serena
author_sort Bonfiglio, Giulia
collection PubMed
description In Crohn’s disease (CD) patients, intestinal dysbiosis with an overgrowth of Proteobacteria, mainly Escherichia coli, has been reported. A new pathotype of E. coli, the adherent-invasive Escherichia coli strain (AIEC), has been isolated from the mucosae of CD patients. AIEC strains play an important role in CD pathogenesis, increasing intestinal mucosa damage and inflammation. Several studies have been undertaken to find possible strategies/treatments aimed at AIEC strain reduction/elimination from CD patients’ intestinal mucosae. To date, a truly effective strategy against AIEC overgrowth is not yet available, and as such, further investigations are warranted. Bdellovibrio bacteriovorus is a predator bacterium which lives by invading Gram-negative bacteria, and is usually present both in natural and human ecosystems. The aim of this study was to evaluate a novel possible strategy to treat CD patients’ mucosae when colonized by AIEC strains, based on the utilization of the Gram-negative predatory bacteria, B. bacteriovorus. The overall results indicate that B. bacteriovorus is able to interfere with important steps in the dynamics of pathogenicity of AIEC strains by its predatory activity. We indicate, for the first time, the possibility of counteracting AIEC strain overgrowth by exploiting what naturally occurs in microbial ecosystems (i.e., predation).
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spelling pubmed-70232812020-03-12 Growth Control of Adherent-Invasive Escherichia coli (AIEC) by the Predator Bacteria Bdellovibrio bacteriovorus: A New Therapeutic Approach for Crohn’s Disease Patients Bonfiglio, Giulia Neroni, Bruna Radocchia, Giulia Pompilio, Arianna Mura, Francesco Trancassini, Maria Di Bonaventura, Giovanni Pantanella, Fabrizio Schippa, Serena Microorganisms Article In Crohn’s disease (CD) patients, intestinal dysbiosis with an overgrowth of Proteobacteria, mainly Escherichia coli, has been reported. A new pathotype of E. coli, the adherent-invasive Escherichia coli strain (AIEC), has been isolated from the mucosae of CD patients. AIEC strains play an important role in CD pathogenesis, increasing intestinal mucosa damage and inflammation. Several studies have been undertaken to find possible strategies/treatments aimed at AIEC strain reduction/elimination from CD patients’ intestinal mucosae. To date, a truly effective strategy against AIEC overgrowth is not yet available, and as such, further investigations are warranted. Bdellovibrio bacteriovorus is a predator bacterium which lives by invading Gram-negative bacteria, and is usually present both in natural and human ecosystems. The aim of this study was to evaluate a novel possible strategy to treat CD patients’ mucosae when colonized by AIEC strains, based on the utilization of the Gram-negative predatory bacteria, B. bacteriovorus. The overall results indicate that B. bacteriovorus is able to interfere with important steps in the dynamics of pathogenicity of AIEC strains by its predatory activity. We indicate, for the first time, the possibility of counteracting AIEC strain overgrowth by exploiting what naturally occurs in microbial ecosystems (i.e., predation). MDPI 2019-12-20 /pmc/articles/PMC7023281/ /pubmed/31861852 http://dx.doi.org/10.3390/microorganisms8010017 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bonfiglio, Giulia
Neroni, Bruna
Radocchia, Giulia
Pompilio, Arianna
Mura, Francesco
Trancassini, Maria
Di Bonaventura, Giovanni
Pantanella, Fabrizio
Schippa, Serena
Growth Control of Adherent-Invasive Escherichia coli (AIEC) by the Predator Bacteria Bdellovibrio bacteriovorus: A New Therapeutic Approach for Crohn’s Disease Patients
title Growth Control of Adherent-Invasive Escherichia coli (AIEC) by the Predator Bacteria Bdellovibrio bacteriovorus: A New Therapeutic Approach for Crohn’s Disease Patients
title_full Growth Control of Adherent-Invasive Escherichia coli (AIEC) by the Predator Bacteria Bdellovibrio bacteriovorus: A New Therapeutic Approach for Crohn’s Disease Patients
title_fullStr Growth Control of Adherent-Invasive Escherichia coli (AIEC) by the Predator Bacteria Bdellovibrio bacteriovorus: A New Therapeutic Approach for Crohn’s Disease Patients
title_full_unstemmed Growth Control of Adherent-Invasive Escherichia coli (AIEC) by the Predator Bacteria Bdellovibrio bacteriovorus: A New Therapeutic Approach for Crohn’s Disease Patients
title_short Growth Control of Adherent-Invasive Escherichia coli (AIEC) by the Predator Bacteria Bdellovibrio bacteriovorus: A New Therapeutic Approach for Crohn’s Disease Patients
title_sort growth control of adherent-invasive escherichia coli (aiec) by the predator bacteria bdellovibrio bacteriovorus: a new therapeutic approach for crohn’s disease patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023281/
https://www.ncbi.nlm.nih.gov/pubmed/31861852
http://dx.doi.org/10.3390/microorganisms8010017
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