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Dendropanax morbifera Protects against Renal Fibrosis in Streptozotocin-Induced Diabetic Rats
The aquatic extract of Dendropanax morbifera (DP) is typically consumed as a beverage in Korea and China and is also used in various traditional medicines. However, the functional role of DP on diabetes-induced renal fibrosis is unclear. Here, the protective effects of DP extract against diabetes-in...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023400/ https://www.ncbi.nlm.nih.gov/pubmed/31963869 http://dx.doi.org/10.3390/antiox9010084 |
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author | Sachan, Richa Kundu, Amit Dey, Prasanta Son, Ji Yeon Kim, Kyeong Seok Lee, Da Eun Kim, Hae Ri Park, Jae Hyeon Lee, Su Hyun Kim, Jung-Hwan Cao, Shugeng Lee, Byung Mu Kwak, Jong Hwan Kim, Hyung Sik |
author_facet | Sachan, Richa Kundu, Amit Dey, Prasanta Son, Ji Yeon Kim, Kyeong Seok Lee, Da Eun Kim, Hae Ri Park, Jae Hyeon Lee, Su Hyun Kim, Jung-Hwan Cao, Shugeng Lee, Byung Mu Kwak, Jong Hwan Kim, Hyung Sik |
author_sort | Sachan, Richa |
collection | PubMed |
description | The aquatic extract of Dendropanax morbifera (DP) is typically consumed as a beverage in Korea and China and is also used in various traditional medicines. However, the functional role of DP on diabetes-induced renal fibrosis is unclear. Here, the protective effects of DP extract against diabetes-induced renal fibrosis were evaluated. Streptozotocin (STZ, 60 mg/kg) was injected intraperitoneally in rats to induce diabetes. After 5 days, DP extract (25 mg/kg/day) and metformin (50 mg/kg/day) were administered orally to diabetic rats for 28 days. DP administration protected both body and organ weight loss in STZ-treated diabetic rats. Significant improvements in serum blood urea nitrogen (BUN), creatinine, and oxidative stress parameters were observed in diabetic rats by DP administration. DP extract markedly protected diabetic-induced histopathological damages in the kidney and pancreas. A significant reduction was observed in microalbumin, kidney injury molecule-1 (KIM-1), selenium binding protein-1 (SBP1), and pyruvate kinase muscle isozyme M2 (PKM2) levels in the urinary excretion of diabetic rats after the administration of DP extract. The expression of pro-inflammatory cytokines and fibrosis marker levels were significantly reduced in the kidney of diabetic rats. Our results strongly indicate that DP extract exhibits protective activity against diabetes-induced renal fibrosis through ameliorating oxidative stress and inflammation. Therefore, we suggest that DP extract can be used as a preventive agent on the progression of diabetic nephropathy and renal fibrosis. |
format | Online Article Text |
id | pubmed-7023400 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70234002020-03-12 Dendropanax morbifera Protects against Renal Fibrosis in Streptozotocin-Induced Diabetic Rats Sachan, Richa Kundu, Amit Dey, Prasanta Son, Ji Yeon Kim, Kyeong Seok Lee, Da Eun Kim, Hae Ri Park, Jae Hyeon Lee, Su Hyun Kim, Jung-Hwan Cao, Shugeng Lee, Byung Mu Kwak, Jong Hwan Kim, Hyung Sik Antioxidants (Basel) Article The aquatic extract of Dendropanax morbifera (DP) is typically consumed as a beverage in Korea and China and is also used in various traditional medicines. However, the functional role of DP on diabetes-induced renal fibrosis is unclear. Here, the protective effects of DP extract against diabetes-induced renal fibrosis were evaluated. Streptozotocin (STZ, 60 mg/kg) was injected intraperitoneally in rats to induce diabetes. After 5 days, DP extract (25 mg/kg/day) and metformin (50 mg/kg/day) were administered orally to diabetic rats for 28 days. DP administration protected both body and organ weight loss in STZ-treated diabetic rats. Significant improvements in serum blood urea nitrogen (BUN), creatinine, and oxidative stress parameters were observed in diabetic rats by DP administration. DP extract markedly protected diabetic-induced histopathological damages in the kidney and pancreas. A significant reduction was observed in microalbumin, kidney injury molecule-1 (KIM-1), selenium binding protein-1 (SBP1), and pyruvate kinase muscle isozyme M2 (PKM2) levels in the urinary excretion of diabetic rats after the administration of DP extract. The expression of pro-inflammatory cytokines and fibrosis marker levels were significantly reduced in the kidney of diabetic rats. Our results strongly indicate that DP extract exhibits protective activity against diabetes-induced renal fibrosis through ameliorating oxidative stress and inflammation. Therefore, we suggest that DP extract can be used as a preventive agent on the progression of diabetic nephropathy and renal fibrosis. MDPI 2020-01-19 /pmc/articles/PMC7023400/ /pubmed/31963869 http://dx.doi.org/10.3390/antiox9010084 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sachan, Richa Kundu, Amit Dey, Prasanta Son, Ji Yeon Kim, Kyeong Seok Lee, Da Eun Kim, Hae Ri Park, Jae Hyeon Lee, Su Hyun Kim, Jung-Hwan Cao, Shugeng Lee, Byung Mu Kwak, Jong Hwan Kim, Hyung Sik Dendropanax morbifera Protects against Renal Fibrosis in Streptozotocin-Induced Diabetic Rats |
title | Dendropanax morbifera Protects against Renal Fibrosis in Streptozotocin-Induced Diabetic Rats |
title_full | Dendropanax morbifera Protects against Renal Fibrosis in Streptozotocin-Induced Diabetic Rats |
title_fullStr | Dendropanax morbifera Protects against Renal Fibrosis in Streptozotocin-Induced Diabetic Rats |
title_full_unstemmed | Dendropanax morbifera Protects against Renal Fibrosis in Streptozotocin-Induced Diabetic Rats |
title_short | Dendropanax morbifera Protects against Renal Fibrosis in Streptozotocin-Induced Diabetic Rats |
title_sort | dendropanax morbifera protects against renal fibrosis in streptozotocin-induced diabetic rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023400/ https://www.ncbi.nlm.nih.gov/pubmed/31963869 http://dx.doi.org/10.3390/antiox9010084 |
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