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In Vitro, Ex Vivo and In Vivo Evaluation of Microcontainers for Oral Delivery of Insulin
Enhancing the oral bioavailability of peptides has received a lot of attention for decades but remains challenging, partly due to low intestinal membrane permeability. Combining a permeation enhancer (PE) with unidirectionally releasing microcontainers (MCs) has previously been shown to increase ins...
Autores principales: | Jørgensen, Jacob Rune, Yu, Feiyang, Venkatasubramanian, Ramakrishnan, Nielsen, Line Hagner, Nielsen, Hanne Mørck, Boisen, Anja, Rades, Thomas, Müllertz, Anette |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023435/ https://www.ncbi.nlm.nih.gov/pubmed/31936066 http://dx.doi.org/10.3390/pharmaceutics12010048 |
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