Actively Targeted and Redox Responsive Delivery of Anticancer Drug by Chitosan Nanoparticles

The clinical efficacy of methotrexate (MTX) is limited by its poor water solubility, its low bioavailability, and the development of resistance in cancer cells. Herein, we developed novel folate redox-responsive chitosan (FTC) nanoparticles for intracellular MTX delivery. l-Cysteine and folic acid m...

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Detalles Bibliográficos
Autores principales: Mazzotta, Elisabetta, De Benedittis, Selene, Qualtieri, Antonio, Muzzalupo, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023447/
https://www.ncbi.nlm.nih.gov/pubmed/31888000
http://dx.doi.org/10.3390/pharmaceutics12010026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023447/
https://www.ncbi.nlm.nih.gov/pubmed/31888000
http://dx.doi.org/10.3390/pharmaceutics12010026

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