From Translation to Protein Degradation as Mechanisms for Regulating Biological Functions: A Review on the SLRP Family in Skeletal Tissues

The extracellular matrix can trigger cellular responses through its composition and structure. Major extracellular matrix components are the proteoglycans, which are composed of a core protein associated with glycosaminoglycans, among which the small leucine-rich proteoglycans (SLRPs) are the larges...

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Detalles Bibliográficos
Autores principales: Zappia, Jérémie, Joiret, Marc, Sanchez, Christelle, Lambert, Cécile, Geris, Liesbet, Muller, Marc, Henrotin, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023458/
https://www.ncbi.nlm.nih.gov/pubmed/31947880
http://dx.doi.org/10.3390/biom10010080
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author Zappia, Jérémie
Joiret, Marc
Sanchez, Christelle
Lambert, Cécile
Geris, Liesbet
Muller, Marc
Henrotin, Yves
author_facet Zappia, Jérémie
Joiret, Marc
Sanchez, Christelle
Lambert, Cécile
Geris, Liesbet
Muller, Marc
Henrotin, Yves
author_sort Zappia, Jérémie
collection PubMed
description The extracellular matrix can trigger cellular responses through its composition and structure. Major extracellular matrix components are the proteoglycans, which are composed of a core protein associated with glycosaminoglycans, among which the small leucine-rich proteoglycans (SLRPs) are the largest family. This review highlights how the codon usage pattern can be used to modulate cellular response and discusses the biological impact of post-translational events on SLRPs, including the substitution of glycosaminoglycan moieties, glycosylation, and degradation. These modifications are listed, and their impacts on the biological activities and structural properties of SLRPs are described. We narrowed the topic to skeletal tissues undergoing dynamic remodeling.
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spelling pubmed-70234582020-03-12 From Translation to Protein Degradation as Mechanisms for Regulating Biological Functions: A Review on the SLRP Family in Skeletal Tissues Zappia, Jérémie Joiret, Marc Sanchez, Christelle Lambert, Cécile Geris, Liesbet Muller, Marc Henrotin, Yves Biomolecules Review The extracellular matrix can trigger cellular responses through its composition and structure. Major extracellular matrix components are the proteoglycans, which are composed of a core protein associated with glycosaminoglycans, among which the small leucine-rich proteoglycans (SLRPs) are the largest family. This review highlights how the codon usage pattern can be used to modulate cellular response and discusses the biological impact of post-translational events on SLRPs, including the substitution of glycosaminoglycan moieties, glycosylation, and degradation. These modifications are listed, and their impacts on the biological activities and structural properties of SLRPs are described. We narrowed the topic to skeletal tissues undergoing dynamic remodeling. MDPI 2020-01-03 /pmc/articles/PMC7023458/ /pubmed/31947880 http://dx.doi.org/10.3390/biom10010080 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zappia, Jérémie
Joiret, Marc
Sanchez, Christelle
Lambert, Cécile
Geris, Liesbet
Muller, Marc
Henrotin, Yves
From Translation to Protein Degradation as Mechanisms for Regulating Biological Functions: A Review on the SLRP Family in Skeletal Tissues
title From Translation to Protein Degradation as Mechanisms for Regulating Biological Functions: A Review on the SLRP Family in Skeletal Tissues
title_full From Translation to Protein Degradation as Mechanisms for Regulating Biological Functions: A Review on the SLRP Family in Skeletal Tissues
title_fullStr From Translation to Protein Degradation as Mechanisms for Regulating Biological Functions: A Review on the SLRP Family in Skeletal Tissues
title_full_unstemmed From Translation to Protein Degradation as Mechanisms for Regulating Biological Functions: A Review on the SLRP Family in Skeletal Tissues
title_short From Translation to Protein Degradation as Mechanisms for Regulating Biological Functions: A Review on the SLRP Family in Skeletal Tissues
title_sort from translation to protein degradation as mechanisms for regulating biological functions: a review on the slrp family in skeletal tissues
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023458/
https://www.ncbi.nlm.nih.gov/pubmed/31947880
http://dx.doi.org/10.3390/biom10010080
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