Cargando…

Novel N,N′-Disubstituted Acylselenoureas as Potential Antioxidant and Cytotoxic Agents

Selenium compounds are pivotal in medicinal chemistry for their antitumoral and antioxidant properties. Forty seven acylselenoureas have been designed and synthesized following a fragment-based approach. Different scaffolds, including carbo- and hetero-cycles, along with mono- and bi-cyclic moieties...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ruberte, Ana Carolina, Ramos-Inza, Sandra, Aydillo, Carlos, Talavera, Irene, Encío, Ignacio, Plano, Daniel, Sanmartín, Carmen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023466/ https://www.ncbi.nlm.nih.gov/pubmed/31936213 http://dx.doi.org/10.3390/antiox9010055

Ejemplares similares

Novel N,N′-Disubstituted Selenoureas as Potential Antioxidant and Cytotoxic Agents
por: Calvo-Martín, Gorka, et al.
Publicado: (2021)

Novel Acylselenourea Derivatives: Dual Molecules with Anticancer and Radical Scavenging Activity
por: Astrain-Redin, Nora, et al.
Publicado: (2023)

First Generation of Antioxidant Precursors for Bioisosteric Se-NSAIDs: Design, Synthesis, and In Vitro and In Vivo Anticancer Evaluation
por: Ramos-Inza, Sandra, et al.
Publicado: (2023)

New Formulation of a Methylseleno-Aspirin Analog with Anticancer Activity Towards Colon Cancer
por: Ruberte, Ana Carolina, et al.
Publicado: (2020)

New Amides and Phosphoramidates Containing Selenium: Studies on Their Cytotoxicity and Antioxidant Activities in Breast Cancer
por: Etxebeste-Mitxeltorena, Mikel, et al.
Publicado: (2021)

Unveiling a New Selenocyanate as a Multitarget Candidate with Anticancer, Antileishmanial and Antibacterial Potential
por: Ramos-Inza, Sandra, et al.
Publicado: (2022)

Vilsmeier reagent, NaHSe and diclofenac acid chloride: one-pot synthesis of a novel selenoindolinone with potent anticancer activity
por: Ruberte, Ana Carolina, et al.
Publicado: (2020)

Synthesis and Pharmacological Screening of Several Aroyl and Heteroaroyl Selenylacetic Acid Derivatives as Cytotoxic and Antiproliferative Agents
por: Sanmartín, Carmen, et al.
Publicado: (2009)

Novel Methylselenoesters as Antiproliferative Agents
por: Díaz-Argelich, Nuria, et al.
Publicado: (2017)

Synthesis, Cytotoxicity, and Antileishmanial Activity of N,N'-Disubstituted Ethylenediamine and Imidazolidine Derivatives
por: de Carvalho, Gustavo S. G., et al.
Publicado: (2010)

Seleno-Analogs of Scaffolds Resembling Natural Products a Novel Warhead toward Dual Compounds
por: Astrain-Redin, Nora, et al.
Publicado: (2023)

A diphenyldiselenide derivative induces autophagy via JNK in HTB‐54 lung cancer cells
por: Díaz, Marta, et al.
Publicado: (2017)

Mechanistic Insights into the Photoisomerization of N,N′‐Disubstituted Indigos
por: Budzák, Šimon, et al.
Publicado: (2022)

Novel Cholinesterase Inhibitors Based on O-Aromatic N,N-Disubstituted Carbamates and Thiocarbamates
por: Krátký, Martin, et al.
Publicado: (2016)

A Synthetic Method to Access Symmetric and Non-Symmetric 2-(N,N'-disubstituted)guanidinebenzothiazoles
por: Cruz, Alejandro, et al.
Publicado: (2012)

Synthesis and Evaluation of In Vitro Antibacterial and Antitumor Activities of Novel N,N-Disubstituted Schiff Bases
por: Luo, Heng, et al.
Publicado: (2017)

N(1),N(3)-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase
por: Novikov, Mikhail S., et al.
Publicado: (2013)

Recent Advances in Catalytic and Technology-Driven Radical Addition to N,N-Disubstituted Iminium Species
por: Oudeyer, Sylvain, et al.
Publicado: (2023)

Electrochemical synthesis of N,N′-disubstituted indazolin-3-ones via an intramolecular anodic dehydrogenative N–N coupling reaction
por: Bieniek, Jessica C., et al.
Publicado: (2022)

SAR study on N(2),N(4)-disubstituted pyrimidine-2,4-diamines as effective CDK2/CDK9 inhibitors and antiproliferative agents
por: Jing, Liandong, et al.
Publicado: (2018)

Norbornene and Related Structures as Scaffolds in the Search for New Cancer Treatments
por: Calvo-Martín, Gorka, et al.
Publicado: (2022)

Synthesis of New Fused Benzothiadiazepines and Macrocyclic Sulfamides Starting from N,N-Disubstituted Sulfamides and N(Boc)-Sulfamides
por: Dehamchia, Mohamed, et al.
Publicado: (2012)

Antileishmanial Activity of a Series of N(2),N(4)-Disubstituted Quinazoline-2,4-diamines
por: Van Horn, Kurt S., et al.
Publicado: (2014)

One-pot synthesis of symmetric imidazolium ionic liquids N,N-disubstituted with long alkyl chains
por: Damilano, Giacomo, et al.
Publicado: (2020)

Photosynthesis-Inhibiting Activity of N-(Disubstituted-phenyl)-3-hydroxynaphthalene-2-carboxamides †
por: Kos, Jiri, et al.
Publicado: (2021)

Synthesis and Identification of New N,N-Disubstituted Thiourea, and Thiazolidinone Scaffolds Based on Quinolone Moiety as Urease Inhibitor
por: Elshaier, Yaseen A. M. M., et al.
Publicado: (2022)

Multicolor emission based on a N, N′—Disubstituted dihydrodibenzo [a, c] phenazine crown ether macrocycle
por: Ma, Chang-Shun, et al.
Publicado: (2022)

Disubstituted 4-Chloro-3-nitrophenylthiourea Derivatives: Antimicrobial and Cytotoxic Studies
por: Bielenica, Anna, et al.
Publicado: (2018)

Investigation of the Mechanisms of Cytotoxic Activity of 1,3-Disubstituted Thiourea Derivatives
por: Strzyga-Łach, Paulina, et al.
Publicado: (2021)

Governing the emissive properties of 4-aminobiphenyl-2-pyrimidine push–pull systems via the restricted torsion of N,N-disubstituted amino groups
por: Cortés-Villena, Alejandro, et al.
Publicado: (2023)

Tyrosol Derivatives, Bearing 3,5-Disubstituted Isoxazole and 1,4-Disubstituted Triazole, as Potential Antileukemia Agents by Promoting Apoptosis
por: Abdelkafi-Koubaa, Zaineb, et al.
Publicado: (2022)

Catalytic Enantioselective Synthesis of N-C Axially Chiral N-(2,6-Disubstituted-phenyl)sulfonamides through Chiral Pd-Catalyzed N-Allylation
por: Fukasawa, Sota, et al.
Publicado: (2022)

N,N-disubstituted azines attenuate LPS-mediated neuroinflammation in microglia and neuronal apoptosis via inhibiting MAPK signaling pathways
por: Subedi, Lalita, et al.
Publicado: (2017)

Design, Synthesis, and Biological Evaluation of N,N-Disubstituted-4-arylthiazole-2-methylamine Derivatives as Cholesteryl Ester Transfer Inhibitors
por: Wang, Xinran, et al.
Publicado: (2017)

Antiviral Activity of N(1),N(3)-Disubstituted Uracil Derivatives against SARS-CoV-2 Variants of Concern
por: Siniavin, Andrei E., et al.
Publicado: (2022)

Substituent Effects on the N–H Bond Dissociation Enthalpies, Ionization Energies, Acidities, and Radical Scavenging Behavior of 3,7-Disubstituted Phenoxazines and 3,7-Disubstituted Phenothiazines
por: Thao, Pham Thi Thu, et al.
Publicado: (2020)

Enantioselective synthesis of gem-disubstituted N-Boc diazaheterocycles via decarboxylative asymmetric allylic alkylation
por: Sun, Alexander W., et al.
Publicado: (2018)

Synthesis, Structure and In Vitro Cytotoxic Activity of Novel Cinchona—Chalcone Hybrids with 1,4-Disubstituted- and 1,5-Disubstituted 1,2,3-Triazole Linkers
por: Jernei, Tamás, et al.
Publicado: (2019)

Room-Temperature Spin Crossover in a Solution of Iron(II) Complexes with N,N′-Disubstituted Bis(pyrazol-3-yl)pyridines
por: Aleshin, Dmitry Yu, et al.
Publicado: (2021)

Small change for big improvement in the preparation of the key intermediate N(1), N(3)-disubstituted 1,3,5-triazone of ensitrelvir
por: Hu, Wei, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_tj10lo8v4op6a8sv3pld3tlpe7