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Redox Signaling from Mitochondria: Signal Propagation and Its Targets
Progress in mass spectroscopy of posttranslational oxidative modifications has enabled researchers to experimentally verify the concept of redox signaling. We focus here on redox signaling originating from mitochondria under physiological situations, discussing mechanisms of transient redox burst in...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023504/ https://www.ncbi.nlm.nih.gov/pubmed/31935965 http://dx.doi.org/10.3390/biom10010093 |
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author | Ježek, Petr Holendová, Blanka Plecitá-Hlavatá, Lydie |
author_facet | Ježek, Petr Holendová, Blanka Plecitá-Hlavatá, Lydie |
author_sort | Ježek, Petr |
collection | PubMed |
description | Progress in mass spectroscopy of posttranslational oxidative modifications has enabled researchers to experimentally verify the concept of redox signaling. We focus here on redox signaling originating from mitochondria under physiological situations, discussing mechanisms of transient redox burst in mitochondria, as well as the possible ways to transfer such redox signals to specific extramitochondrial targets. A role of peroxiredoxins is described which enables redox relay to other targets. Examples of mitochondrial redox signaling are discussed: initiation of hypoxia-inducible factor (HIF) responses; retrograde redox signaling to PGC1α during exercise in skeletal muscle; redox signaling in innate immune cells; redox stimulation of insulin secretion, and other physiological situations. |
format | Online Article Text |
id | pubmed-7023504 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70235042020-03-12 Redox Signaling from Mitochondria: Signal Propagation and Its Targets Ježek, Petr Holendová, Blanka Plecitá-Hlavatá, Lydie Biomolecules Review Progress in mass spectroscopy of posttranslational oxidative modifications has enabled researchers to experimentally verify the concept of redox signaling. We focus here on redox signaling originating from mitochondria under physiological situations, discussing mechanisms of transient redox burst in mitochondria, as well as the possible ways to transfer such redox signals to specific extramitochondrial targets. A role of peroxiredoxins is described which enables redox relay to other targets. Examples of mitochondrial redox signaling are discussed: initiation of hypoxia-inducible factor (HIF) responses; retrograde redox signaling to PGC1α during exercise in skeletal muscle; redox signaling in innate immune cells; redox stimulation of insulin secretion, and other physiological situations. MDPI 2020-01-06 /pmc/articles/PMC7023504/ /pubmed/31935965 http://dx.doi.org/10.3390/biom10010093 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ježek, Petr Holendová, Blanka Plecitá-Hlavatá, Lydie Redox Signaling from Mitochondria: Signal Propagation and Its Targets |
title | Redox Signaling from Mitochondria: Signal Propagation and Its Targets |
title_full | Redox Signaling from Mitochondria: Signal Propagation and Its Targets |
title_fullStr | Redox Signaling from Mitochondria: Signal Propagation and Its Targets |
title_full_unstemmed | Redox Signaling from Mitochondria: Signal Propagation and Its Targets |
title_short | Redox Signaling from Mitochondria: Signal Propagation and Its Targets |
title_sort | redox signaling from mitochondria: signal propagation and its targets |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023504/ https://www.ncbi.nlm.nih.gov/pubmed/31935965 http://dx.doi.org/10.3390/biom10010093 |
work_keys_str_mv | AT jezekpetr redoxsignalingfrommitochondriasignalpropagationanditstargets AT holendovablanka redoxsignalingfrommitochondriasignalpropagationanditstargets AT plecitahlavatalydie redoxsignalingfrommitochondriasignalpropagationanditstargets |