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Redox Signaling from Mitochondria: Signal Propagation and Its Targets

Progress in mass spectroscopy of posttranslational oxidative modifications has enabled researchers to experimentally verify the concept of redox signaling. We focus here on redox signaling originating from mitochondria under physiological situations, discussing mechanisms of transient redox burst in...

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Detalles Bibliográficos
Autores principales: Ježek, Petr, Holendová, Blanka, Plecitá-Hlavatá, Lydie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023504/
https://www.ncbi.nlm.nih.gov/pubmed/31935965
http://dx.doi.org/10.3390/biom10010093
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author Ježek, Petr
Holendová, Blanka
Plecitá-Hlavatá, Lydie
author_facet Ježek, Petr
Holendová, Blanka
Plecitá-Hlavatá, Lydie
author_sort Ježek, Petr
collection PubMed
description Progress in mass spectroscopy of posttranslational oxidative modifications has enabled researchers to experimentally verify the concept of redox signaling. We focus here on redox signaling originating from mitochondria under physiological situations, discussing mechanisms of transient redox burst in mitochondria, as well as the possible ways to transfer such redox signals to specific extramitochondrial targets. A role of peroxiredoxins is described which enables redox relay to other targets. Examples of mitochondrial redox signaling are discussed: initiation of hypoxia-inducible factor (HIF) responses; retrograde redox signaling to PGC1α during exercise in skeletal muscle; redox signaling in innate immune cells; redox stimulation of insulin secretion, and other physiological situations.
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spelling pubmed-70235042020-03-12 Redox Signaling from Mitochondria: Signal Propagation and Its Targets Ježek, Petr Holendová, Blanka Plecitá-Hlavatá, Lydie Biomolecules Review Progress in mass spectroscopy of posttranslational oxidative modifications has enabled researchers to experimentally verify the concept of redox signaling. We focus here on redox signaling originating from mitochondria under physiological situations, discussing mechanisms of transient redox burst in mitochondria, as well as the possible ways to transfer such redox signals to specific extramitochondrial targets. A role of peroxiredoxins is described which enables redox relay to other targets. Examples of mitochondrial redox signaling are discussed: initiation of hypoxia-inducible factor (HIF) responses; retrograde redox signaling to PGC1α during exercise in skeletal muscle; redox signaling in innate immune cells; redox stimulation of insulin secretion, and other physiological situations. MDPI 2020-01-06 /pmc/articles/PMC7023504/ /pubmed/31935965 http://dx.doi.org/10.3390/biom10010093 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ježek, Petr
Holendová, Blanka
Plecitá-Hlavatá, Lydie
Redox Signaling from Mitochondria: Signal Propagation and Its Targets
title Redox Signaling from Mitochondria: Signal Propagation and Its Targets
title_full Redox Signaling from Mitochondria: Signal Propagation and Its Targets
title_fullStr Redox Signaling from Mitochondria: Signal Propagation and Its Targets
title_full_unstemmed Redox Signaling from Mitochondria: Signal Propagation and Its Targets
title_short Redox Signaling from Mitochondria: Signal Propagation and Its Targets
title_sort redox signaling from mitochondria: signal propagation and its targets
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023504/
https://www.ncbi.nlm.nih.gov/pubmed/31935965
http://dx.doi.org/10.3390/biom10010093
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