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Xanthan Gum–Konjac Glucomannan Blend Hydrogel for Wound Healing

Hydrogels are considered to be the most ideal materials for the production of wound dressings since they display a three-dimensional structure that mimics the native extracellular matrix of skin as well as a high-water content, which confers a moist environment at the wound site. Until now, differen...

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Autores principales: Alves, Andreia, Miguel, Sónia P., Araujo, André R.T.S., de Jesús Valle, María José, Sánchez Navarro, Amparo, Correia, Ilídio J., Ribeiro, Maximiano P., Coutinho, Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023620/
https://www.ncbi.nlm.nih.gov/pubmed/31947937
http://dx.doi.org/10.3390/polym12010099
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author Alves, Andreia
Miguel, Sónia P.
Araujo, André R.T.S.
de Jesús Valle, María José
Sánchez Navarro, Amparo
Correia, Ilídio J.
Ribeiro, Maximiano P.
Coutinho, Paula
author_facet Alves, Andreia
Miguel, Sónia P.
Araujo, André R.T.S.
de Jesús Valle, María José
Sánchez Navarro, Amparo
Correia, Ilídio J.
Ribeiro, Maximiano P.
Coutinho, Paula
author_sort Alves, Andreia
collection PubMed
description Hydrogels are considered to be the most ideal materials for the production of wound dressings since they display a three-dimensional structure that mimics the native extracellular matrix of skin as well as a high-water content, which confers a moist environment at the wound site. Until now, different polymers have been used, alone or blended, for the production of hydrogels aimed for this biomedical application. From the best of our knowledge, the application of a xanthan gum–konjac glucomannan blend has not been used for the production of wound dressings. Herein, a thermo-reversible hydrogel composed of xanthan gum–konjac glucomannan (at different concentrations (1% and 2% w/v) and ratios (50/50 and 60/40)) was produced and characterized. The obtained data emphasize the excellent physicochemical and biological properties of the produced hydrogels, which are suitable for their future application as wound dressings.
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spelling pubmed-70236202020-03-11 Xanthan Gum–Konjac Glucomannan Blend Hydrogel for Wound Healing Alves, Andreia Miguel, Sónia P. Araujo, André R.T.S. de Jesús Valle, María José Sánchez Navarro, Amparo Correia, Ilídio J. Ribeiro, Maximiano P. Coutinho, Paula Polymers (Basel) Article Hydrogels are considered to be the most ideal materials for the production of wound dressings since they display a three-dimensional structure that mimics the native extracellular matrix of skin as well as a high-water content, which confers a moist environment at the wound site. Until now, different polymers have been used, alone or blended, for the production of hydrogels aimed for this biomedical application. From the best of our knowledge, the application of a xanthan gum–konjac glucomannan blend has not been used for the production of wound dressings. Herein, a thermo-reversible hydrogel composed of xanthan gum–konjac glucomannan (at different concentrations (1% and 2% w/v) and ratios (50/50 and 60/40)) was produced and characterized. The obtained data emphasize the excellent physicochemical and biological properties of the produced hydrogels, which are suitable for their future application as wound dressings. MDPI 2020-01-04 /pmc/articles/PMC7023620/ /pubmed/31947937 http://dx.doi.org/10.3390/polym12010099 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alves, Andreia
Miguel, Sónia P.
Araujo, André R.T.S.
de Jesús Valle, María José
Sánchez Navarro, Amparo
Correia, Ilídio J.
Ribeiro, Maximiano P.
Coutinho, Paula
Xanthan Gum–Konjac Glucomannan Blend Hydrogel for Wound Healing
title Xanthan Gum–Konjac Glucomannan Blend Hydrogel for Wound Healing
title_full Xanthan Gum–Konjac Glucomannan Blend Hydrogel for Wound Healing
title_fullStr Xanthan Gum–Konjac Glucomannan Blend Hydrogel for Wound Healing
title_full_unstemmed Xanthan Gum–Konjac Glucomannan Blend Hydrogel for Wound Healing
title_short Xanthan Gum–Konjac Glucomannan Blend Hydrogel for Wound Healing
title_sort xanthan gum–konjac glucomannan blend hydrogel for wound healing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023620/
https://www.ncbi.nlm.nih.gov/pubmed/31947937
http://dx.doi.org/10.3390/polym12010099
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