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Multicompartmental Mesoporous Silica/Polymer Nanostructured Hybrids: Design Capabilities by Integrating Linear and Star-Shaped Block Copolymers

Poly(2-vinyl pyridine)-b-poly(ethylene oxide) (P2VP-b-PEO) linear diblock copolymer and polystyrene–poly(ethylene oxide) (PS(10)PEO(10)) heteroarm star copolymer were used as building elements to prepare organic–inorganic hybrids. By using the layer-by-layer (LbL) methodology, these elements were in...

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Autores principales: Iatridi, Zacharoula, Evangelatou, Kyriaki, Theodorakis, Nikolaos, Angelopoulou, Athina, Avgoustakis, Konstantinos, Tsitsilianis, Constantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023666/
https://www.ncbi.nlm.nih.gov/pubmed/31906238
http://dx.doi.org/10.3390/polym12010051
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author Iatridi, Zacharoula
Evangelatou, Kyriaki
Theodorakis, Nikolaos
Angelopoulou, Athina
Avgoustakis, Konstantinos
Tsitsilianis, Constantinos
author_facet Iatridi, Zacharoula
Evangelatou, Kyriaki
Theodorakis, Nikolaos
Angelopoulou, Athina
Avgoustakis, Konstantinos
Tsitsilianis, Constantinos
author_sort Iatridi, Zacharoula
collection PubMed
description Poly(2-vinyl pyridine)-b-poly(ethylene oxide) (P2VP-b-PEO) linear diblock copolymer and polystyrene–poly(ethylene oxide) (PS(10)PEO(10)) heteroarm star copolymer were used as building elements to prepare organic–inorganic hybrids. By using the layer-by-layer (LbL) methodology, these elements were integrated on mesoporous silica through non-covalent interactions, namely, ionic and H-bonding. For the latter, tannic acid (TA) was used as an intermediate layer. The deposition of the various layers was monitored by thermogravimetric analysis (TGA), electrophoretic measurements, and confocal microscopy. The final silica hybrid, bearing alternating P2VP-b-PEO and PS(10)PEO(10) star layers was capable of carrying one hydrophilic and two hydrophobic chemical species in distinct compartments. These multicompartmental organic–inorganic hybrids could be used as nanostructured carriers for pH-responsive multiple drug delivery and potential theranostic applications.
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spelling pubmed-70236662020-03-11 Multicompartmental Mesoporous Silica/Polymer Nanostructured Hybrids: Design Capabilities by Integrating Linear and Star-Shaped Block Copolymers Iatridi, Zacharoula Evangelatou, Kyriaki Theodorakis, Nikolaos Angelopoulou, Athina Avgoustakis, Konstantinos Tsitsilianis, Constantinos Polymers (Basel) Article Poly(2-vinyl pyridine)-b-poly(ethylene oxide) (P2VP-b-PEO) linear diblock copolymer and polystyrene–poly(ethylene oxide) (PS(10)PEO(10)) heteroarm star copolymer were used as building elements to prepare organic–inorganic hybrids. By using the layer-by-layer (LbL) methodology, these elements were integrated on mesoporous silica through non-covalent interactions, namely, ionic and H-bonding. For the latter, tannic acid (TA) was used as an intermediate layer. The deposition of the various layers was monitored by thermogravimetric analysis (TGA), electrophoretic measurements, and confocal microscopy. The final silica hybrid, bearing alternating P2VP-b-PEO and PS(10)PEO(10) star layers was capable of carrying one hydrophilic and two hydrophobic chemical species in distinct compartments. These multicompartmental organic–inorganic hybrids could be used as nanostructured carriers for pH-responsive multiple drug delivery and potential theranostic applications. MDPI 2019-12-31 /pmc/articles/PMC7023666/ /pubmed/31906238 http://dx.doi.org/10.3390/polym12010051 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Iatridi, Zacharoula
Evangelatou, Kyriaki
Theodorakis, Nikolaos
Angelopoulou, Athina
Avgoustakis, Konstantinos
Tsitsilianis, Constantinos
Multicompartmental Mesoporous Silica/Polymer Nanostructured Hybrids: Design Capabilities by Integrating Linear and Star-Shaped Block Copolymers
title Multicompartmental Mesoporous Silica/Polymer Nanostructured Hybrids: Design Capabilities by Integrating Linear and Star-Shaped Block Copolymers
title_full Multicompartmental Mesoporous Silica/Polymer Nanostructured Hybrids: Design Capabilities by Integrating Linear and Star-Shaped Block Copolymers
title_fullStr Multicompartmental Mesoporous Silica/Polymer Nanostructured Hybrids: Design Capabilities by Integrating Linear and Star-Shaped Block Copolymers
title_full_unstemmed Multicompartmental Mesoporous Silica/Polymer Nanostructured Hybrids: Design Capabilities by Integrating Linear and Star-Shaped Block Copolymers
title_short Multicompartmental Mesoporous Silica/Polymer Nanostructured Hybrids: Design Capabilities by Integrating Linear and Star-Shaped Block Copolymers
title_sort multicompartmental mesoporous silica/polymer nanostructured hybrids: design capabilities by integrating linear and star-shaped block copolymers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023666/
https://www.ncbi.nlm.nih.gov/pubmed/31906238
http://dx.doi.org/10.3390/polym12010051
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