Treatment de-escalation for HPV-associated oropharyngeal squamous cell carcinoma with radiotherapy vs. trans-oral surgery (ORATOR2): study protocol for a randomized phase II trial

BACKGROUND: Patients with human papillomavirus-positive (HPV+) oropharyngeal squamous cell carcinoma (OPC) have substantially better treatment response and overall survival (OS) than patients with HPV-negative disease. Treatment options for HPV+ OPC can involve either a primary radiotherapy (RT) app...

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Detalles Bibliográficos
Autores principales: Nichols, Anthony C., Lang, Pencilla, Prisman, Eitan, Berthelet, Eric, Tran, Eric, Hamilton, Sarah, Wu, Jonn, Fung, Kevin, de Almeida, John R., Bayley, Andrew, Goldstein, David P., Eskander, Antoine, Husain, Zain, Bahig, Houda, Christopoulous, Apostolos, Hier, Michael, Sultanem, Khalil, Richardson, Keith, Mlynarek, Alex, Krishnan, Suren, Le, Hien, Yoo, John, MacNeil, S. Danielle, Mendez, Adrian, Winquist, Eric, Read, Nancy, Venkatesan, Varagur, Kuruvilla, Sara, Warner, Andrew, Mitchell, Sylvia, Corsten, Martin, Rajaraman, Murali, Johnson-Obaseki, Stephanie, Eapen, Libni, Odell, Michael, Chandarana, Shamir, Banerjee, Robyn, Dort, Joseph, Matthews, T. Wayne, Hart, Robert, Kerr, Paul, Dowthwaite, Samuel, Gupta, Michael, Zhang, Han, Wright, Jim, Parker, Christina, Wehrli, Bret, Kwan, Keith, Theurer, Julie, Palma, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023689/
https://www.ncbi.nlm.nih.gov/pubmed/32059705
http://dx.doi.org/10.1186/s12885-020-6607-z

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