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Comparison of clinical features and outcomes between HBV-related and non-B non-C hepatocellular carcinoma
OBJECTIVE: To evaluate the difference between hepatitis B virus related hepatocellular carcinoma (HBV-HCC) and non-HBV non-HCV hepatocellular carcinoma (NBNC-HCC) patients based on clinical features and prognosis. METHODS: A total of 175 patients with HCC were enrolled. Patients’ characteristics wer...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023697/ https://www.ncbi.nlm.nih.gov/pubmed/32082414 http://dx.doi.org/10.1186/s13027-020-0273-2 |
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author | Xue, Xiulan Liao, Wei Xing, Yugang |
author_facet | Xue, Xiulan Liao, Wei Xing, Yugang |
author_sort | Xue, Xiulan |
collection | PubMed |
description | OBJECTIVE: To evaluate the difference between hepatitis B virus related hepatocellular carcinoma (HBV-HCC) and non-HBV non-HCV hepatocellular carcinoma (NBNC-HCC) patients based on clinical features and prognosis. METHODS: A total of 175 patients with HCC were enrolled. Patients’ characteristics were extracted from medical records. Among them, 107 patients were positive for HBsAg and negative for HCV-Ab while 68 patients were negative for HBsAg and HCV-Ab. RESULTS: The patients in the NBNC-HCC group were significantly older than those in the HBV-HCC group (P = 0.045). Moreover, vascular invasion was found in 23.4% of HBV-HCC patients, which was significantly higher than that in the NBNC-HCC patients with 10.3% (P = 0.029). Kaplan-Meier analysis revealed that HBV-HCC patients had significantly worse outcomes in terms of overall survival (P = 0.036). Compared with the NBNC-HCC patients, the HBV-HCC patients had a significantly worse disease-free survival (P = 0.0018). The multivariate analysis results indicated that TNM stage (HR = 1.541, 95%CI 1.072–2.412, P = 0.002) and HBV infection (HR = 1.087, 95%CI 1.012–1.655, P = 0.042) were independent risk variables for overall survival. While vascular invasion (HR = 1.562, 95%CI 1.013–2.815, P = 0.042) and HBV infection (HR = 1.650, 95%CI 1.017–2.676, P = 0.037) were independent risk factors associated with disease-free survival. CONCLUSION: Our data revealed that HBV-HCC is more common in young males with vascular invasion, while NBNC-HCC occurs mostly in elderly patients, and overall survival rate is significantly better than that of HBV-HCC. Our study therefore provides evidence that patients with HBV-HCC require closer follow-up due to their poor prognosis. |
format | Online Article Text |
id | pubmed-7023697 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-70236972020-02-20 Comparison of clinical features and outcomes between HBV-related and non-B non-C hepatocellular carcinoma Xue, Xiulan Liao, Wei Xing, Yugang Infect Agent Cancer Research Article OBJECTIVE: To evaluate the difference between hepatitis B virus related hepatocellular carcinoma (HBV-HCC) and non-HBV non-HCV hepatocellular carcinoma (NBNC-HCC) patients based on clinical features and prognosis. METHODS: A total of 175 patients with HCC were enrolled. Patients’ characteristics were extracted from medical records. Among them, 107 patients were positive for HBsAg and negative for HCV-Ab while 68 patients were negative for HBsAg and HCV-Ab. RESULTS: The patients in the NBNC-HCC group were significantly older than those in the HBV-HCC group (P = 0.045). Moreover, vascular invasion was found in 23.4% of HBV-HCC patients, which was significantly higher than that in the NBNC-HCC patients with 10.3% (P = 0.029). Kaplan-Meier analysis revealed that HBV-HCC patients had significantly worse outcomes in terms of overall survival (P = 0.036). Compared with the NBNC-HCC patients, the HBV-HCC patients had a significantly worse disease-free survival (P = 0.0018). The multivariate analysis results indicated that TNM stage (HR = 1.541, 95%CI 1.072–2.412, P = 0.002) and HBV infection (HR = 1.087, 95%CI 1.012–1.655, P = 0.042) were independent risk variables for overall survival. While vascular invasion (HR = 1.562, 95%CI 1.013–2.815, P = 0.042) and HBV infection (HR = 1.650, 95%CI 1.017–2.676, P = 0.037) were independent risk factors associated with disease-free survival. CONCLUSION: Our data revealed that HBV-HCC is more common in young males with vascular invasion, while NBNC-HCC occurs mostly in elderly patients, and overall survival rate is significantly better than that of HBV-HCC. Our study therefore provides evidence that patients with HBV-HCC require closer follow-up due to their poor prognosis. BioMed Central 2020-02-14 /pmc/articles/PMC7023697/ /pubmed/32082414 http://dx.doi.org/10.1186/s13027-020-0273-2 Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Xue, Xiulan Liao, Wei Xing, Yugang Comparison of clinical features and outcomes between HBV-related and non-B non-C hepatocellular carcinoma |
title | Comparison of clinical features and outcomes between HBV-related and non-B non-C hepatocellular carcinoma |
title_full | Comparison of clinical features and outcomes between HBV-related and non-B non-C hepatocellular carcinoma |
title_fullStr | Comparison of clinical features and outcomes between HBV-related and non-B non-C hepatocellular carcinoma |
title_full_unstemmed | Comparison of clinical features and outcomes between HBV-related and non-B non-C hepatocellular carcinoma |
title_short | Comparison of clinical features and outcomes between HBV-related and non-B non-C hepatocellular carcinoma |
title_sort | comparison of clinical features and outcomes between hbv-related and non-b non-c hepatocellular carcinoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023697/ https://www.ncbi.nlm.nih.gov/pubmed/32082414 http://dx.doi.org/10.1186/s13027-020-0273-2 |
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