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Comparison of clinical features and outcomes between HBV-related and non-B non-C hepatocellular carcinoma

OBJECTIVE: To evaluate the difference between hepatitis B virus related hepatocellular carcinoma (HBV-HCC) and non-HBV non-HCV hepatocellular carcinoma (NBNC-HCC) patients based on clinical features and prognosis. METHODS: A total of 175 patients with HCC were enrolled. Patients’ characteristics wer...

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Autores principales: Xue, Xiulan, Liao, Wei, Xing, Yugang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023697/
https://www.ncbi.nlm.nih.gov/pubmed/32082414
http://dx.doi.org/10.1186/s13027-020-0273-2
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author Xue, Xiulan
Liao, Wei
Xing, Yugang
author_facet Xue, Xiulan
Liao, Wei
Xing, Yugang
author_sort Xue, Xiulan
collection PubMed
description OBJECTIVE: To evaluate the difference between hepatitis B virus related hepatocellular carcinoma (HBV-HCC) and non-HBV non-HCV hepatocellular carcinoma (NBNC-HCC) patients based on clinical features and prognosis. METHODS: A total of 175 patients with HCC were enrolled. Patients’ characteristics were extracted from medical records. Among them, 107 patients were positive for HBsAg and negative for HCV-Ab while 68 patients were negative for HBsAg and HCV-Ab. RESULTS: The patients in the NBNC-HCC group were significantly older than those in the HBV-HCC group (P = 0.045). Moreover, vascular invasion was found in 23.4% of HBV-HCC patients, which was significantly higher than that in the NBNC-HCC patients with 10.3% (P = 0.029). Kaplan-Meier analysis revealed that HBV-HCC patients had significantly worse outcomes in terms of overall survival (P = 0.036). Compared with the NBNC-HCC patients, the HBV-HCC patients had a significantly worse disease-free survival (P = 0.0018). The multivariate analysis results indicated that TNM stage (HR = 1.541, 95%CI 1.072–2.412, P = 0.002) and HBV infection (HR = 1.087, 95%CI 1.012–1.655, P = 0.042) were independent risk variables for overall survival. While vascular invasion (HR = 1.562, 95%CI 1.013–2.815, P = 0.042) and HBV infection (HR = 1.650, 95%CI 1.017–2.676, P = 0.037) were independent risk factors associated with disease-free survival. CONCLUSION: Our data revealed that HBV-HCC is more common in young males with vascular invasion, while NBNC-HCC occurs mostly in elderly patients, and overall survival rate is significantly better than that of HBV-HCC. Our study therefore provides evidence that patients with HBV-HCC require closer follow-up due to their poor prognosis.
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spelling pubmed-70236972020-02-20 Comparison of clinical features and outcomes between HBV-related and non-B non-C hepatocellular carcinoma Xue, Xiulan Liao, Wei Xing, Yugang Infect Agent Cancer Research Article OBJECTIVE: To evaluate the difference between hepatitis B virus related hepatocellular carcinoma (HBV-HCC) and non-HBV non-HCV hepatocellular carcinoma (NBNC-HCC) patients based on clinical features and prognosis. METHODS: A total of 175 patients with HCC were enrolled. Patients’ characteristics were extracted from medical records. Among them, 107 patients were positive for HBsAg and negative for HCV-Ab while 68 patients were negative for HBsAg and HCV-Ab. RESULTS: The patients in the NBNC-HCC group were significantly older than those in the HBV-HCC group (P = 0.045). Moreover, vascular invasion was found in 23.4% of HBV-HCC patients, which was significantly higher than that in the NBNC-HCC patients with 10.3% (P = 0.029). Kaplan-Meier analysis revealed that HBV-HCC patients had significantly worse outcomes in terms of overall survival (P = 0.036). Compared with the NBNC-HCC patients, the HBV-HCC patients had a significantly worse disease-free survival (P = 0.0018). The multivariate analysis results indicated that TNM stage (HR = 1.541, 95%CI 1.072–2.412, P = 0.002) and HBV infection (HR = 1.087, 95%CI 1.012–1.655, P = 0.042) were independent risk variables for overall survival. While vascular invasion (HR = 1.562, 95%CI 1.013–2.815, P = 0.042) and HBV infection (HR = 1.650, 95%CI 1.017–2.676, P = 0.037) were independent risk factors associated with disease-free survival. CONCLUSION: Our data revealed that HBV-HCC is more common in young males with vascular invasion, while NBNC-HCC occurs mostly in elderly patients, and overall survival rate is significantly better than that of HBV-HCC. Our study therefore provides evidence that patients with HBV-HCC require closer follow-up due to their poor prognosis. BioMed Central 2020-02-14 /pmc/articles/PMC7023697/ /pubmed/32082414 http://dx.doi.org/10.1186/s13027-020-0273-2 Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Xue, Xiulan
Liao, Wei
Xing, Yugang
Comparison of clinical features and outcomes between HBV-related and non-B non-C hepatocellular carcinoma
title Comparison of clinical features and outcomes between HBV-related and non-B non-C hepatocellular carcinoma
title_full Comparison of clinical features and outcomes between HBV-related and non-B non-C hepatocellular carcinoma
title_fullStr Comparison of clinical features and outcomes between HBV-related and non-B non-C hepatocellular carcinoma
title_full_unstemmed Comparison of clinical features and outcomes between HBV-related and non-B non-C hepatocellular carcinoma
title_short Comparison of clinical features and outcomes between HBV-related and non-B non-C hepatocellular carcinoma
title_sort comparison of clinical features and outcomes between hbv-related and non-b non-c hepatocellular carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023697/
https://www.ncbi.nlm.nih.gov/pubmed/32082414
http://dx.doi.org/10.1186/s13027-020-0273-2
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